Effects of the PD-1 PD-L1 signaling pathway on the functionality of NK cells in the tumor microenvironment of patients with head and neck cancerdoi:10.1055/s-0041-1727967Kansy, BConcha-Benavente, FMoskovitz, JMoy, JChandran, ULang, S...
PD-1’s extracellular region consists of a single IgV-like domain, and its cytoplasmic region contains an immunoreceptor tyrosine-based inhibitory motif (ITIM) and an immunoreceptor tyrosine-based switch motif (ITSM). Upon ligation with its physiological ligand (PD-L1 or PD-L2), PD-1 suppresses...
Here we show that the immunomodulatory PD-1–PD-L1 pathway is highly active in regenerative neonatal hearts but rapidly silenced later in life. Deletion of the PD-1 receptor or inactivation of its ligand PD-L1 prevented regeneration of neonatal hearts after injury. Disruption of the pathway ...
pathway:(1)blocking direct interaction between PD-1 and PD-L1;(2)inhibiting transcription and translation of PD-L1;and(3)promoting degradation of PD-L1 protein.The development of these small molecule inhibitors opens a new ...
The emergence of programmed death-1 (PD-1) and programmed death ligand 1 (PD-L1) immunosuppressants provides new therapeutic directions for various advanced malignant cancers. At present, PD-1/PD-L1 immunosuppressants have made significant progress in cl
PD-1 / PD-L1 Pathway Immunotherapy Product Focus. Tumor cells take advantage of the PD-1 pathway to evade the immune system. Consequently, many pharmaceutical companies have been developing drugs to inhibit PD-1 and PD-L1.
The role of PD-1 and PD-L1 in T-cell immune suppression and the potential for immunotherapy via blocking PD-1 and PD-L1 in hematological malignancies are also reviewed. 展开 关键词: Oncology Hematology DOI: 10.1186/1756-8722-6-74
Yonghong Zhang1,*, Zhaozhao Liu1,*, Guoqiang Sun2, Gil Mor3 & Aihua Liao1 The programmed cell death-1(PD-1)/PD-ligand 1 (PD-L1) pathway is critical to immune homeostasis by promoting regulatory T (Treg) development and inhibiting effector T (such as Th17) cell responses....
mechanisms of PD-L1 expression and its effect on T-cells (“The PD-1:PD-L1 T-cells inhibitory checkpoint”); 4 - clinico-pathological correlation and prognostic value of PD-L1 expression in tumors (PD-L1 expression and significance in tumors); and, 5 and 6 -, the role of PD-L1 in ...
This phenomenon may be one of the reasons why immature leukemic progenitor cells escape the immune system i.e., by inhibiting T-cell function via the PD-1/PD-L1 pathway [12]. Structural features of PD-1 and PD-L1 The PD-1 gene is a CD28 family member that is a member of the ...