Effects of the PD-1 PD-L1 signaling pathway on the functionality of NK cells in the tumor microenvironment of patients with head and neck cancerdoi:10.1055/s-0041-1727967Kansy, BConcha-Benavente, FMoskovitz, JMoy, JChandran, ULang, S...
Here we show that the immunomodulatory PD-1–PD-L1 pathway is highly active in regenerative neonatal hearts but rapidly silenced later in life. Deletion of the PD-1 receptor or inactivation of its ligand PD-L1 prevented regeneration of neonatal hearts after injury. Disruption of the pathway ...
2) What is the best combination therapy using PD-1 blockade? 3) What predictive biomarkers can be used to distinguish responsive and unresponsive patients? Here we review the development of immunotherapy targeting the PD-1/PD-L1 signaling pathway and discuss the issues that still need to be ...
The emergence of programmed death-1 (PD-1) and programmed death ligand 1 (PD-L1) immunosuppressants provides new therapeutic directions for various advanced malignant cancers. At present, PD-1/PD-L1 immunosuppressants have made significant progress in cl
PD-1 / PD-L1 Pathway Immunotherapy Product Focus. Tumor cells take advantage of the PD-1 pathway to evade the immune system. Consequently, many pharmaceutical companies have been developing drugs to inhibit PD-1 and PD-L1.
Given that the PD-1/PD-L1 pathway is critical for downregulating the immune responses of gliomas, we reviewed its expression, the mediated immunosuppressive mechanisms, and the clinical applications of PD-1/PD-L1 inhibitors. We also considered potential treatment strategies and the challenges that ...
mechanisms of PD-L1 expression and its effect on T-cells (“The PD-1:PD-L1 T-cells inhibitory checkpoint”); 4 - clinico-pathological correlation and prognostic value of PD-L1 expression in tumors (PD-L1 expression and significance in tumors); and, 5 and 6 -, the role of PD-L1 in ...
The PD-1 costimulatory receptor negatively regulates T cell receptor signaling upon interacting with its ligands PDL1 and PDL2 expressed on antigen presenting cells (APCs) and has a key role in maintaining self-tolerance. In the present study we examined the role of PD-1 in Histoplasma capsula...
Yonghong Zhang1,*, Zhaozhao Liu1,*, Guoqiang Sun2, Gil Mor3 & Aihua Liao1 The programmed cell death-1(PD-1)/PD-ligand 1 (PD-L1) pathway is critical to immune homeostasis by promoting regulatory T (Treg) development and inhibiting effector T (such as Th17) cell responses....
The programmed cell death-1(PD-1)/PD-ligand 1 (PD-L1) pathway is critical to immune homeostasis by promoting regulatory T (Treg) development and inhibiting effector T (such as Th17) cell responses. However, the association between the PD-1/PD-L1 pathway and the Treg/Th17 imbalance has no...