2025年3月10日，复旦大学附属华山医院刘杰教授、骆菲菲研究员团队在Cancer Cell发表题为“Targeting tumor monocyte-intrinsic PD-L1 by rewiring STING signaling and enhancing STING agonist therapy”的研究论文，揭示了STING激动剂诱导单核细胞内源性PD-L1介导免疫抑制的全新机制，并提出通过STING信号重编程提升治疗疗...
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PD-1/PD-L1通路阻断剂，包括PD-1单克隆抗体(纳武单抗nivolumab,帕博丽珠单抗pembrolizumab，西米单抗cemiplimab)以及PD-L1单克隆抗体(阿特珠单抗atezolizumab,阿维鲁单抗avelumab,德瓦鲁单抗durvalumab)是包括黑色素瘤、乳腺癌、结直肠癌、非小细胞肺癌、小细胞肺癌、肾细胞癌、皮肤鳞状细胞癌以及血液系统肿瘤在内的多种...
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CD80/PD-L1 signaling up-regulates VCAM-1 through ERK and NF魏B-p65. PD-1 and CD80 blockade reduces tumor egress of PD-1high fragile Tregs and Teffs into draining lymph nodes, respectively, and promotes tumor regression. These data provide roles for PD-L1 in cell migration and immune ...
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2022年12月3日,在头颈肿瘤的PD-1/L1靶向治疗研究领域,南京大学医学院附属口腔医院丁亮副研究员、泥艳红教授和王志勇教授合作团队在国际肿瘤学期刊British Journal of Cancer(影响因子: 9.075,中科院一区)上在线发表题为“IL-33/ST2 signaling promotes constitutive and inductive PD-L1 expression and immune escape ...