Ni X,Song Q,Cassady K,et al. PD-L1 interacts with CD80 to regulate graftversus-leukemia activity of donor CD8 + T cells[J]. J Clin Invest,2017,127( 5) : 1960. TAO LL,LAI X,WEI J.PD -1 /PD -L signaling pathway in chronic hepatitis B[J].J Clin Hepatol,2016,32( 12) : 237...
Ai L, Xu A, Xu J. Roles of PD-1/PD-L1 Pathway: Signaling, Cancer, and Beyond.Adv Exp M...
Mechanism of PD1/PDL1 signaling pathway regulating Treg/Th17 in the occurrence and development of preeclampsia PD‑1/PD‑L1Treg/Th17PREECLAMPSIAObjective:To detect the expression levels of programmed cell death 1(PD1)and its ligand PDL1,regulatory cell(Treg)and T helper cell 17(Th17)specific ...
(1)基因组水平的改变(genomic aberrations); (2)炎症信号通路(inflammatory signaling); (3)肿瘤信号通路(oncogenic signaling); (4)miRNA水平的调控(microRNA-based control); (5)转录后水平调控(posttranslationalmodulation)。 调节PD-L1表达的机制总览 是不是似曾相识?大家有没有想起我们以前写过的这篇文章:lnc...
2024年1月，Cell上发文题为“SMARCAL1 is a dual regulator of innate immune signaling and PD-L1 ...
Although clinical studies have shown promise for targeting PD1/PDL1 signaling in non–small cell lung cancer (NSCLC), the regulation of PDL1 expression is poorly understood. Here, we show that PDL1 is regulated by p53 via miR-34. p53 wild-type and p53-deficient cell lines (p53–/–and ...
(2)炎症信号通路(inflammatory signaling); (3)肿瘤信号通路(oncogenic signaling); (4)miRNA水平的调控(microRNA-based control); (5)转录后水平调控(posttranslationalmodulation)。 调节PD-L1表达的机制总览 是不是似曾相识?大家有没有想起我们以前写过的这篇文章:lncRNA差异表达的原因(上游机制)有哪些?(附文章...
Precisiontreatmentstrategiestargetingdifferenttypesoftumorsandpatientgroupsarealsofutureresearchdirections.Throughin-depthresearchontheregulatorymechanismsofthePD-1/PD-L1signalingpathwayindifferenttumors,combinedwithmultiomicstechnologiessuchasgenomicsandproteomics,itisexpectedtoprovidemorepersonalizedandprecisetreatmentplansfor...
HCC-CAF-primed neutrophils impaired T-cell function through the PD1/PDL1 signaling pathway. We revealed that HCC-CAFs induced the activation of STAT3 pathways in neutrophils, which are essential for the survival and function of activated neutrophils. In addition, we demonstrated that HCC-CAF-...
这些蛋白质是cosignaling分子，在整个T细胞功能的所有阶段发挥重要作用的CD28-B7家族的成员。在PD-1受体（...