Ni X,Song Q,Cassady K,et al. PD-L1 interacts with CD80 to regulate graftversus-leukemia activity of donor CD8 + T cells[J]. J Clin Invest,2017,127( 5) : 1960. TAO LL,LAI X,WEI J.PD -1 /PD -L signaling pathway in chronic hepatitis B[J].J Clin Hepatol,2016,32( 12) : 237...
PDL1 inhibited IFN signal transduction through a conserved class of sequence motifs that mediate crosstalk with IFN signaling. Abrogation of PDL1 expression or antibody-mediated PDL1 blockade strongly sensitized cancer cells to IFN cytotoxicity through a STAT3/caspase-7-dependent pathway. Moreover, ...
(1)基因组水平的改变(genomic aberrations); (2)炎症信号通路(inflammatory signaling); (3)肿瘤信号通路(oncogenic signaling); (4)miRNA水平的调控(microRNA-based control); (5)转录后水平调控(posttranslationalmodulation)。 调节PD-L1表达的机制总览 是不是似曾相识?大家有没有想起我们以前写过的这篇文章:lnc...
(1) 基因组异常：PD-L1的表达可由于基因的突变、扩增或重排导致。例如，某些肿瘤中存在的EML4-ALK融合...
vital immune response pathways. These responses assist the body in resisting the invasion of pathogens such as viruses and tumors. In addition to tumor DNA, STING can also sense cyclic dinucleotide natural ligands produced by bacteria to activate downstream signaling pathways. This reveals the ...
2024年1月，Cell上发文题为“SMARCAL1is a dual regulator of innate immune signaling and PD-L1 ...
This receptor, programmed death receptor 1 (PD-1), has been shown to negatively regulate T-cell receptor (TCR) signaling. Upon ligating its receptor, PD-L1 has been reported to decrease TCR-mediated proliferation and cytokine production. PD-L1 expression was ...
Osteosarcoma, a malignant bone tumor often characterized by high hedgehog signaling activity, residual tumor cells, and substantial bone defects, poses significant challenges to both treatment response and postsurgical recovery. Here, we developed a nanocomposite hydrogel for the sustained co-delivery of ...
HCC-CAF-primed neutrophils impaired T-cell function through the PD1/PDL1 signaling pathway. We revealed that HCC-CAFs induced the activation of STAT3 pathways in neutrophils, which are essential for the survival and function of activated neutrophils. In addition, we demonstrated that HCC-CAF-...
This signaling pathway may inhibit antitumor immune responses in gastric carcinoma. B7-H1 expression plays a critical role in the pathogenesis of human gastric carcinoma,and might be a promising prognostic marker and therapeutic target in the treatment of this disease. [11]Liu S M, Meng Q, ...