TAO LL,LAI X,WEI J.PD -1 /PD -L signaling pathway in chronic hepatitis B[J].J Clin Hepatol,2016,32( 12) : 2373 -2378.( in Chinese) 陶丽琳,赖欣,韦嘉.PD -1/PD -L信号通路在慢性HBV感染免疫反应中的作用[J].临床肝胆病杂志,2016,32( 12) : 2373 -2378. AHN J,BISHOP JA,RODEN RBS...
Metformin inhibits human non-small cell lung cancer by regulating AMPK–CEBPB–PDL1 signaling pathwayMetforminCEBPBPDL1NSCLCMetformin has been found to have inhibitory effects on a variety of tumors. However, its effects on non-small cell lung cancer (NSCLC) remain unclear. We demonstrated that ...
参考资料：Ai L, Xu A, Xu J. Roles of PD-1/PD-L1 Pathway: Signaling, Cancer, and Beyond....
正常生理状况下，PD-1/PD-L1抑制性共刺激信号的主要作用是防止T细胞不受控制地过度活化攻击正常细胞。不同类型肿瘤细胞表面表达高水平的PD-L1，这些过度表达的PD-L1通过PD-1/PD-L1信号途径诱导T细胞衰竭，使肿瘤细胞逃避T细胞免疫攻击，直接影响肿瘤患者的治疗效果及临床预后。PD-1/PD-L1通路阻断剂，包括PD-1单克...
This signaling pathway may inhibit antitumor immune responses in gastric carcinoma. B7-H1 expression plays a critical role in the pathogenesis of human gastric carcinoma,and might be a promising prognostic marker and therapeutic target in the treatment of this disease. [11]Liu S M, Meng Q, ...
HCC-CAF-primed neutrophils impaired T cell immunity through the PD1/PDL1 signaling pathway. We revealed that HCC-CAFs stimulated the activation of the STAT3 pathways in neutrophils, which was essential for the functions of activated neutrophils. In addition, we demonstrated that HCC-CAF-derived IL...
The cGAS-STING signaling pathway is a cytoplasmic DNA sensing pathway that plays a critical role in innate immune responses. Understanding this signaling pathway is extremely important for studying drug targets and treatment strategies. When tumor DNA is sensed by cGAS in the cytoplasm, cGAS catalyse...
immune responsesignal transductioncell surface receptor signaling pathwaypositive regulation of cell migrationT cell costimulationnegative regulation of interferon-gamma productionnegative regulation of interleukin-10 productionresponse to cytokinepositive regulation of T cell prol...
G.J.F. has patents or pending royalties on the PD1–PDL1 pathway from Roche, Merck MSD, Bristol-Myers-Squibb, Merck KGA, Boehringer-Ingelheim, AstraZeneca, Dako, Leica, Mayo Clinic and Novartis. G.J.F. has served on advisory boards for Roche, Bristol-Myers-Squibb, Xios, Origimed, Tri...
(αPD-L1), and hedgehog pathway antagonist vismodegib, to eradicate residual tumor cells while promoting bone regeneration post-surgery. In a mouse model of tibia osteosarcoma, this hydrogel-mediated combination therapy led to remarkable tumor growth inhibition and hence increased animal survival by ...