3. Garcia-Diaz, A. et al. Interferon Receptor Signaling Pathways Regulating PD-L1 and PD-L2 Expression. Cell reports 19, 1189-1201 (2017).4. Boussiotis, V.A. Molecular and Biochemical Aspects of the PD-1 Checkpoint Pathway. N Engl J Med 375, 1767-1778 (2016).5. Jiang, Y., Li, ...
PurposeTo identify radiosensitive genes in PD-L1 expression and PD-1 check point pathway in cancer.Methods and MaterialsGene expression datasets and information were downloaded from TCGA. Stepwise multivariate Cox regression based on AIC was performed using stacking multiple interpolation data to identify...
”在我的“教诲有方”下,沈老师在2010年分别在Virology Journal 和Journal of Medical Virology上发了两篇文章:“PD-1 expression on peripheral CD8+ TEM/TEMRA subsets closely correlated with HCV viral load in chronic hepatitis C patients”[2]和“Increased PD-L1 Expression and PD-L1...
2:PD-L1 Expression asa Predictive Biomarker in Cancer Immunotherapy. Mol Cancer Ther. 2015Apr;14(4):847-56. 3:Pan-tumor genomicbiomarkers for PD-1 checkpoint blockade–based immunotherapy. Science 362, 197(2018)
学术前沿 | 预测PD-1/PD-L1检查点抑制剂疗效的生物标志物形态比较:系统性回顾与Meta分析 前言 近年来,出现了很多包括肿瘤突变负荷(TMB)、程序性死亡配体1(PD-L1)蛋白的表达、基因表达图谱(GEP)、使用多重免疫组化/免疫荧光(mIHC/IF)的多个量化蛋白作为预测免疫疗效的生物标志物。TMB作为标志物基于这样一个概念:...
非小细胞肺癌PD-L1免疫组织化学检测规范中国专家共识 01 引言 近年来,以程序性死亡受体1(programmed death-1, PD-1)/PD配体1(PD ligand 1, PD-L1)免疫检查点抑制剂为主的免疫治疗在晚期肺癌中取得了突破性的进展,改变了该领域的治疗...
中文检索词:(胃癌* OR胃肿瘤* OR食管胃结合部肿瘤* OR食管胃结合部癌*)AND PD-1 AND PD-L1。另手动检索所选文章和评论的参考文献,以获得所有可能相关的研究。所有检索文献不限语种。 1.2 纳入与排除标准 纳入文献均为PD-1/PD-L1表达与胃癌患者预后...
Background: Checkpoint inhibitors (PD-1, PD-L1) are revolutionizing the oncology disease management process. Despite the fact that gastric cancer is a common malignancy with a poor prognosis, relatively little attention has been drawn and attracted to the treatment and diagnosis of this disease by...
程序性细胞死亡蛋白1(programmed cell death protein 1,PD-1)/程序性死亡配体1(programmed death-ligand 1,PD-L1)是导致肿瘤免疫逃逸的重要免疫检查点分子,阻断PD-1/PD-L1可以重新激活细胞毒性T细胞对肿瘤的杀伤作用,是一种重要的肿瘤免疫治疗方式。肿瘤细胞中PD-L1的表达可能影响抗PD-1/PD-L1治疗的临床疗效。
improved objective response rates, progression-free survival and overall survival, independent of PD-L1 expression status and CD8 T cell density. These results pave the way for using TLS detection to select patients who are more likely to benefit from immune checkpoint blockade...