3. Garcia-Diaz, A. et al. Interferon Receptor Signaling Pathways Regulating PD-L1 and PD-L2 Expression. Cell reports 19, 1189-1201 (2017).4. Boussiotis, V.A. Molecular and Biochemical Aspects of the PD-1 Checkpoint Pathway. N Engl J Med 375, 1767-1778 (2016).5. Jiang, Y., Li, ...
PurposeTo identify radiosensitive genes in PD-L1 expression and PD-1 check point pathway in cancer.Methods and MaterialsGene expression datasets and information were downloaded from TCGA. Stepwise multivariate Cox regression based on AIC was performed using stacking multiple interpolation data to identify...
Indeed, the PD-1/PD-L1 pathway governs the induction and maintenance of immune tolerance within the tumor microenvironment. Consequently, the regulation of PD-1/PD-L1 immune checkpoint expression is of paramount importance. This review summarizes the mechanisms governing PD1/PD-L1 expression at ...
一、PD-1耐药后换药改善有限 CONTACT-01是一项三期多中心、随机、开放标签的研究,招募的患者是晚期非小细胞肺癌,这些患者之前使用过PD-1或PD-L1抑制剂联合铂类药物后进展。共计有186名患者被招募入组,按照1:1的比例分为研究组和对照组。研究组的患者每3周静脉注射一次1200毫克的PD-L1抑制剂阿替利珠单抗,每天口...
中文检索词:(胃癌* OR胃肿瘤* OR食管胃结合部肿瘤* OR食管胃结合部癌*)AND PD-1 AND PD-L1。另手动检索所选文章和评论的参考文献,以获得所有可能相关的研究。所有检索文献不限语种。 1.2 纳入与排除标准 纳入文献均为PD-1/PD-L1表达与胃癌患者预后...
Expression of PD-L2, the other ligand of PD-1, is more restricted and is found on dendritic cells and macrophages after activation [7]. The relevance of targeting the PD-1/PD-L1 axis in MM has been demonstrated in pre-clinical models, and many clinical trials are ongoing. There are ...
正常生理状况下，PD-1/PD-L1抑制性共刺激信号的主要作用是防止T细胞不受控制地过度活化攻击正常细胞。不同类型肿瘤细胞表面表达高水平的PD-L1，这些过度表达的PD-L1通过PD-1/PD-L1信号途径诱导T细胞衰竭，使肿瘤细胞逃避T细胞免疫攻击，直接影响肿瘤患者的治疗效果及临床预后。PD-1/PD-L1通路阻断剂，包括PD-1单...
在肿瘤微环境中,肿瘤细胞通过高表达PD-L1分子,与T细胞上的受体PD-1结合,传递负性调控信号,显著抑制T细胞的活化与增殖,并调节细胞因子的表达和分泌,使肿瘤细胞逃避机体的免疫监控和杀伤,促进肿瘤进展;而阻断该通路可以增强机体的内源性抗肿瘤免疫效应。...
1.PD-L1信号通路概述 1.1 PD-1 及其配体的结构与分布 PD-1 属于免疫球蛋白超家族Ⅰ型跨膜糖蛋白,由人PDCD1基因编码,该基因位于染色体 2q37. 3位点,其相对分子质量约为55 000,是由288个氨基酸组成的细胞表面单…
Moreover, current single-use immune checkpoint inhibitors (ICIs), such as programmed cell death-1 (PD-1) and programmed cell death-ligand 1 (PD-L1) inhibitors, are only effective for some advanced CRC patients with microsatellite instability-high (MSI-H), and most patients may be unable to...