Interestingly, PD-L1 and PD-L2 genetic alterations were detected only in 11% (3/27) of the tested samples in the study. However, the small sample size and heterogeneity of NHL subtypes in this study may not lead to reliable conclusion on the real incidence of this alteration. ...
Targeting the IDO1 pathway in cancer: from bench to bedside. J Hematol Oncol. 2018;11(1):1–12. Article Google Scholar Zhai L, Ladomersky E, Lauing KL, Wu M, Genet M, Gritsina G, Győrffy B, et al. Infiltrating T cells increase IDO1 expression in glioblastoma and contribute to...
There is growing evidence that the mechanism of the PD‐1/PD‐L1 pathway can be specific for a particular histological cancer type. Interestingly, the data have shown that the PD‐1/PD‐L1 pathway blockade may be effective, especially in the endometrioid type of OC. It is important to ...
图1. PD-1/PD-L1信号通路 参考文献 1. Francisco L M., et al. The PD-1 pathway in tolerance and autoimmunity. Immunological Reviews.2010, 236: 219–42.2. Arlene H S., et al. The function of programmed cell death 1 and its ligands in regulating autoimmunity and infection. NATURE IMMUNO...
需要强调的是,本研究中使用的PD-1抗体不是已经上市的PD-1单抗,而是专门为做基础研究设计的鼠源PD-1单抗。 参考资料: [1].Vivek Verma, Rajeev K Shrimali, Shamim Ahmad, et al. PD-1 blockade in subprimed CD8 cells induce...
PD-1/PD-L1 pathway: Current research in breast cancer Introduction: Immunotherapy has shown encouraging outcomes in breast cancer (BC) treatment in recent years. The programmed cell death ligand 1 (PD-L1) tran... SA Syamsu,M Faruk,N Smaradania,... - 《Breast Disease》 被引量: 0发表: ...
2021年11月,Incyte公司在Journal for ImmunoTherapy of Cancer上报告了口服小分子PD-L1抑制剂INCB086550的I期(NCT03762447)临床数据。据了解,这是首个口服小分子PD-(L)1的人体试验数据。 INCB086550分子结构式(来源:参考6) 截至2021 年 4 月9 日,79 名患者接受了治疗,57.0% 为女性,62.0% 有2线及以上的既往...
[3]Jiawei Zhou. Tumor-Associated Macrophages: Recent Insights and Therapies. Frontiers in Oncology. 2020. [4]https://medicalxpress.com/news/2022-04-pathway-cancerous-tumors-body-immune.html
(生物谷Bioon.com) 参考文献 Wenxiao Jiang et al. The role of lncRNAs and circRNAs in the PD-1/PD-L1 pathway in cancerImmunotherapy. Mol Cancer 2021 Sep 8;20(1):116. doi: 10.1186/s12943-021-01406-7.
1. PD-1的结构 PD-1是在T细胞杂交瘤细胞株进行活化诱导的细胞程序性死亡过程中被发现,因此得名[1],属B7-CD28家族成员之一。 PD-1基因位于人类染色体2q37上,所编码的蛋白是一种相对分子质量为50 kDa-55 kDa的I型跨膜糖蛋白,由于缺乏在近膜处能形成同源二聚体的半胱氨酸,以单体形式表达于细胞膜表面。