Interestingly, PD-L1 and PD-L2 genetic alterations were detected only in 11% (3/27) of the tested samples in the study. However, the small sample size and heterogeneity of NHL subtypes in this study may not lead to reliable conclusion on the real incidence of this alteration. ...
Shaw AT, Sequist LV, Fu X, Azzoli CG,Piotrowska Z, et al. EGFR mutations and ALK rearrangements are associated with low response rates to PD-1 pathway blockade in nonesmall cell lung cancer: a retrospective analysis....
与传统的PD-L1表达水平相比,PD-1/PD-L1共定位评分或许可以更好的筛选出能从PD-1/PD-L1抑制剂中获益的NSCLC患者。 参考文献: [2] Gavrielatou N, Liu Y, Vathiotis I, et al. Association of PD-1/PD-L1 Co-location with Immunotherapy Outcomes in Non-Small Cell Lung Cancer. Clin Cancer Res. 2...
PD-1/PD-L1相互作用抑制T细胞增殖和干扰素-γ (IFN-γ)的产生,导致T细胞存活率降低。一方面,多种转录因子能够触发PD-1的表达。另一方面,多种转录因子能够触发PD-1的表达。CR-C区通过其与NFAT的结合位点与CD4+和CD8+细胞中的NFATc1 (NFAT2)结合,在刺激后检测幼稚T细胞中的抗原(Ag)时,CR-B区可通过c-FOS附着...
PD-1/PD-L1 pathway: Current research in breast cancer Introduction: Immunotherapy has shown encouraging outcomes in breast cancer (BC) treatment in recent years. The programmed cell death ligand 1 (PD-L1) tran... SA Syamsu,M Faruk,N Smaradania,... - 《Breast Disease》 被引量: 0发表: ...
1.Chen G, Huang A C, Zhang W, et al. Exosomal PD-L1 contributes to immunosuppression and is associated with anti-PD-1 response[J]. Nature, 2018. 2.Pedoeem A, Azoulay-Alfaguter I, Strazza M, et al. Programmed death-1 pathway in cancer and autoimmunity[J]. Clinical Immunology, 2014...
[3]Jiawei Zhou. Tumor-Associated Macrophages: Recent Insights and Therapies. Frontiers in Oncology. 2020. [4]https://medicalxpress.com/news/2022-04-pathway-cancerous-tumors-body-immune.html
[4] Han Y, Liu D, Li L. PD-1/PD-L1 pathway: current researches in cancer[J]. Am J Cancer Res, 2020, 10(3): 727-742. [5] Wang Z, Wu X. Study and analysis of antitumor resistance mechanism of PD1/PD-L1 im...
[8] Le DT, Uram JN, Wang H, et al. PD-1 blockade in tumors with mismatchrepair deficiency[J]. N Engl J Med, 2015, 372(26): 2509-2520.DOI:10.1056/NEJMoa1500596 [9] Zou W, Wolchok JD, Chen L. PD-L1(...
SatoH, NiimiA, YasuharaT, et al.DNA double-strand break repair pathway regulates PD-L1 expression in cancer cells[J].Nat Commun, 2017, 8(1): 1751.DOI: 10.1038/s41467-017-01883-9. CoelhoMA, de Carné TrécessonS, RanaS, et al.Oncogenic RAS signaling promotes tumor immunoresistance by...