虽然之前已经证实TAM可以表达PD-1,而PD-1与吞噬功能呈负相关,但作者的数据现在表明,高脂饮食诱导的肥胖会诱导TAM PD-1的表达,这可能归因于肥胖相关的炎性细胞因子、瘦素、胰岛素和游离脂肪酸的增加。 实验结果3 PD-1会削弱巨噬细胞的功能 为了更好地理解PD-1的调节和作用,作者分析了与PD-1+巨噬细胞相关的基...
A method for detecting PD-1 is provided and various diseases including cancer and infectious diseases can be treated by preparing immunocomplexes, bispecific molecules and pharmaceutical compositions containing the antibodies. Furthermore, hyperproliferative diseases such as cancer can also be treated by ...
1.Small Molecule Agents Targeting PD-1 Checkpoint Pathway for Cancer Immunotherapy: Mechanisms of Action and Other Considerations for Their Advanced Development. Front Immunol. 2022 May 2:13:752065. 原文标题 : 靶向PD-1/PD-L1小分子药物:改写肿瘤免疫治疗格局的新希望...
2019 年发表在 Lung Cancer 上的一项中国台湾的研究亦显示[5],在未经治的敏感 EGFR 突变肺腺癌患者中,PD-L1 表达水平与 EGFR-TKI 原发性耐药相关。原发性耐药组中 155 例(22.7%)患者的 PD-L1 TPS ≥50%,而疾病对照组仅 1 例(1.8...
在线发表了题为“A protease-cleavable liposome for co-delivery of anti-PD-L1 and doxorubicin for colon cancer therapy in mice”的研究工作。 肿瘤免疫检查点阻断治疗是一种变革性治疗新策略。其中,细胞程序性死亡受体1(PD-1)和...
and melanoma tumors tended to accumulate Texp cells, with terminal Tex cells dramatically decreased following treatment. This difference was possibly due to a variable degree of immunosuppression in different cancer types, or to the concurrent chemotherapy used in these patients with lung cancer. ...
Cancer immunotherapies, represented by immune checkpoint inhibitors (ICIs), have reshaped the treatment paradigm for both advanced non-small cell lung cancer and small cell lung cancer. Programmed death receptor-1/programmed death receptor ligand-1 (PD-1
Programmed death ligand 1 (PD-L1, CD274) is an essential immune checkpoint protein that binds to programmed death 1 (PD-1) on T-lymphocytes. T cell plays a critical role in killing cancer cells while the cancer cell exhibits immune escape by the expressi
Since the discovery of immune checkpoint proteins, there has been a special interest in developing antibodies that block programmed cell death 1 receptor (PD-1) and programmed cell death receptor ligand 1 (PD-L1) for a subset of cancer patients. PD-1 signaling negatively regulates T cell-mediat...
WoodsDM, SodréAL, VillagraA, et al.HDAC inhibition upregulates PD-1 ligands in melanoma and augments immunotherapy with PD-1 blockade[J].Cancer Immunol Res, 2015, 3(12): 1375-1385.DOI:10.1158/2326-6066.Cir-15-0077-t. HoggSJ, VervoortSJ...