PD-1 signaling limits expression of phospholipid phosphatase 1 and promotes intratumoral CD8+ T cell ferroptosis (https://pubmed.ncbi.nlm.nih.gov/39208806/) PD-1 combination therapy with IL-2 modifies CD8+ T cell exhaustion program(https://www...
We employed flow cytometry of T cells derived from peripheral blood and synovial fluid to validate the results.Our screening process validated established regulators in the proximal PD-1 signaling pathway and unveiled an additional 1,112 unique genes associated with PD-1's capacity to hinder T-...
参考文献: Ai L, Xu A, Xu J. Roles of PD-1/PD-L1 Pathway: Signaling, Cancer, and Beyond.Adv Exp Med Biol. 2020;1248:33-59. doi:10.1007/978-981-15-3266-5_3. 来源:Of Studies/医药速览 2023-07-28
参考文献: Ai L, Xu A, Xu J. Roles of PD-1/PD-L1 Pathway: Signaling, Cancer, and Beyond. Adv Exp Med Biol. 2020;1248:33-59. doi:10.1007/978-981-15-3266-5_3.
4):523-538.[4] Ribas A: Adaptive Immune Resistance: How Cancer Protects from Immune Attack. Cancer Discov 2015, 5(9):915-919.[5] Garcia-Diaz A, Shin DS, Moreno BH, Saco J, Escuin-Ordinas H, Rodriguez GA, Zaretsky JM, Sun L, Hugo W, Wang Xet al: Interferon Receptor Signaling ...
PD-1 signaling in primary T cells. Immunol. Rev. 229, 114–125 (2009). CAS PubMed PubMed Central Google Scholar Nishimura, H., Nose, M., Hiai, H., Minato, N. & Honjo, T. Development of lupus-like autoimmune diseases by disruption of the PD-1 gene encoding an ITIM motif-...
12. Triulzi, T. et al. HER2 signaling regulates the tumor immune microenvironment and trastuzumab efficacy. Oncoimmunology 8, e1512942 (2019).13. Triulzi, T. et al. Early immune modulation by single-agent trastuzumab as a marker of trastuzumab benefit. Br. J. Cancer 119, 1487–1494 (2018...
2024年1月，Cell上发文题为“SMARCAL1is a dual regulator of innate immune signaling and PD-L1 ...
3.Immune Checkpoint Receptors Signaling in T Cells. Int J Mol Sci.2022 Apr; 23(7): 3529. 近期会议 REVIEW 南京.第三届小分子药物创新开发论坛 (2023.9.7-8) 精彩文章继续... *本微信公众号对所有原创、转载的内容、陈述、观点判断均保持中立,推送内容仅供公益性分享,部...
2024年12月26日,国立台湾大学 Lu Yen-Shen教授团队在期刊《Cell Reports Medicine》上发表了题为“Adipocyte-derived ferroptotic signaling mitigates obesity”的研究论文。研究结果表明,对于绝经前ER+/HER2-MBC患者,将HT与抗PD1抗体结合...