Riley JL (2009) PD-1 signaling in primary T cells. Immunol Rev 229:114-125Riley JL. PD-1 signaling in primary T cells. Immunological Reviews. Blackwell Publishing Ltd; 2009; 229: 114-125. https://doi.org/10.1111/j.1600-065X.2009.00767.x PMID: 19426218...
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The contribution of PD-1 to peripheral tolerance is a major mechanism for protection against expansion of self-reactive T-cell clones and autoimmune disease. In this review, we aim to bridge the gaps between our cellular and molecular knowledge of PD-1 signaling in T cells, ICI-induced irAEs...
HIF1α通过直接与髓源性抑制细胞(myeloid-derived suppressor cells，MDSCs)的PD-L1近端启动子结合增加PD-L1的表达[15]，低氧条件下HIF2α可以调节透明细胞肾癌PD-L1的表达[16]。核因子-κB(nuclear factor-κB，NF-κB)也与PD-L1的表达相关。PD-L1基因启动子区存在NF-κB结合位点，Maeda等[17]报道了三阴性...
然而,PD-1抑制促进肿瘤Treg的机制仍旧不清楚。 近期,美国加利福尼亚大学免疫学系Francesco Marangoni研究团队在Cancer Cell杂志在线发表题为Interruption of the intratumor CD8+T cell:Treg crosstalk improves the efficacy of PD-1 immunothe...
PD-1 signaling in primary T cells. Immunol. Rev. 229, 114–125 (2009) Article CAS PubMed PubMed Central Google Scholar Francisco, L. M., Sage, P. T. & Sharpe, A. H. The PD-1 pathway in tolerance and autoimmunity. Immunol. Rev. 236, 219–242 (2010) Article CAS PubMed Pub...
SatoH, NiimiA, YasuharaT, et al.DNA double-strand break repair pathway regulates PD-L1 expression in cancer cells[J].Nat Commun, 2017, 8(1): 1751.DOI:10.1038/s41467-017-01883-9. CoelhoMA, de Carné TrécessonS, RanaS, et al.Oncogeni...
PD-1 antibody therapy reduced the TI Treg cell numbers, but did not directly restore the cytokine production of TI CD8+ T cells in TC-1 lung cancer. Single-cell analysis indicated that PD-1 signaling promoted lipid metabolism, proliferation and suppressive pathways in TI Treg cells. These ...
PD-1 signals via binding its two ligands, PD-L1 and PD-L2 both members of the B7 family. Upon ligand binding, PD-1 signaling inhibits T-cell activation, leading to reduced proliferation, cytokine production, and T-cell death. Additionally, PD-1 is known to play key roles in peripheral ...