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参考文献: Zhang Z, Langenbach M, Sagar S, et al. Efficacy of CTLA-4 checkpoint therapy is dependent on IL-21 signaling to mediate cytotoxic reprogramming of PD-1+CD8+ T cells[J]. Nature Immunology, 2024. 本文作者丨谭硕
Syrian Hamster BKH cells transfected with mouse PD-1 cDNA Reported Applications in vivo blocking of PD-1/PD-L signaling Formulation PBS, pH 7.0 Contains no stabilizers or preservatives Endotoxin <2EU/mg (<0.002EU/μg) Determined by LAL gel clotting assay Purity >95% Determined...
Anti-programmed death-1 (PD-1) immunotherapy that aims to restore T cell activity in cancer patients frequently leads to immune-related adverse events such as colitis. However, the underlying mechanism is still elusive. Here, we find that Pdcd1-deficient
wnt signaling in intestinal epithelial cells and suppresses colon carcinogenesis. PLOS ONE 8, e62223 (2013). [13]J. Liu, S. Yang, Z. Wang, X. Chen, Z. Zhang, Ubiquitin ligase A20 regulates p53 protein in human c...
肿瘤细胞PD-L1/2结合T细胞表面的PD-1,招募磷酸酶至免疫突触,抑制TCR和CD28的信号传导【2】。PD-1抑制剂抗肿瘤原理就是破坏PD-1和其配体结合进而促进抗肿瘤效应T细胞的功能,尤其是CD8+T细胞(专家点评Cell | 叶丽林/唐忠辉/孙倍成合作发...
To identify the potent PD-1-controlled tumor-suppressor programs that prevent T cell transformation upon oncogenic T cell signaling, we induced ITK–SYK expression in vivo in primary CD4+T cells with and withoutPdcd1by injecting tamoxifen intoITK-SYKCD4-CreERT2andITK-SYKCD4-CreERT2;Pdcd1−/...