然而,这些患者癌症和合并症的潜在风险,使得将PD-1信号短时缺陷与抗体介导的免疫响应这两者联系起来颇具挑战。 近期,来自美国Rockefeller University的Masato Ogishi研究组等在Immunity上发表题为Impaired development of memory B cells and antibo...
? 2024Purpose: Clinical application of immunotherapy represented by Programmed Death-1 (PD-1) monoclonal antibody has changed the treatment paradigm for colorectal cancer (CRC), and tumor-infiltrating T lymphocytes are critical for anti-PD-1 therapy in CRC. However, there are few studies on the ...
Exhaustion is thought to be initiated by the binding of PD-1 on T cells to its ligand (PD-L1) which is expressed on epithelial cells and macrophages. PD-1 expression is upregulated in murine models of acute and chronic viral infection, but this has yet to be elucidated in human cells....
Titration of PD-1 expression on T cells demonstrated its potent inhibitory signaling, such that even very low PD-1 expression is able to inhibit TNF-α and IL-2 production as well as T-cell proliferation9. The potency exceeds what might be predicted from its ligand-binding affinity, which ...
Programmed cell death protein 1 (PD-1; encoded by thePDCD1gene), mostly expressed on activated T cells, is an important receptor in T-cell immunity.1,2,3Together with programmed death-ligand 1 (PD-L1: encoded by theCD274gene) PD-1 acts as an inhibitor of T cell activity under normal...
Murine PD-1 mRNA expression has been shown to be correlated with activation-induced apoptosis in a mouse T-cell hybridoma cell line and murine thymocytes [13]. PD-1 is expressed on activated T cells, B cells, and myeloid cells. Human PD-1 is a homolog of murine PD-1 (mPD-1), which...
This review discusses the currently available data concerning negative T-cell regulation via PD-1, the blockade of PD-L1/PD-1 interactions, and the implications for adoptive T-cell therapies. 展开 关键词: Immune evasion Immunotherapy PD L1 T cells Tumor cells ...
Summary. Dysfunctional virus-specific T cells are a hallmark of many chronic viral infections. Recent studies have implicated the inhibitory PD-1/PD-L1 pathway with the functional impairment of T cells. In this respect, we will review the latest research on PD-1/PD-L1 pathway and T-cell exh...
The interaction between programmed cell death ligand 1 (PD-L1), which is expressed on the surface of tumor cells, and programmed cell death 1 (PD-1), which is expressed on T cells, impedes the effective activation of tumor antigen-specific T cells, resul
Enrichment of LAG-3, but not PD-1, on Double Negative T Cells at the Female Genital Tract Juno, Jennifer A.,Lajoie,etc.Enrichment of LAG-3, but not PD-1, on Double Negative T Cells at the Female Genital Tract[J].2014,6(6)... Juno, Jennifer A.Lajoie, JulieStalker, Andrew T.O...