CBX4 promotes antitumor immunity by suppressing Pdcd1 expression in T cells. PMID: 37691307 PD1 signal transduction pathways in T cells. PMID: 28881701 Circulating extracellular vesicles expressing PD1 and PD-L1 predict response and mediate resistance to checkpoint inhibitors immunotherapy in metastatic me...
CBX4 promotes antitumor immunity by suppressing Pdcd1 expression in T cells. PMID: 37691307 PD1 signal transduction pathways in T cells. PMID: 28881701 Circulating extracellular vesicles expressing PD1 and PD-L1 predict response and mediate resistance to checkpoint inhibitors immunotherapy in metastatic me...
ibañez-vea, karine breckpot, grazyna kochan, david escors. pd1 signal transduction pathways in t cells. oncotarget. 2017 apr 19;8(31):51936-51945. doi: 10.18632/oncotarget.17232. ecollection 2017 aug 1. 11. ...
PD1-IL2v elicited substantial infiltration by stem-like CD8+ T cells, resulting in tumor regression and enhanced survival in mice. Combining anti-PD-L1 with PD1-IL2v sustained the response phase, improving therapeutic efficacy both by reprogramming immunosuppressive tumor-associated macrophages and ...
Signal Transduction and Targeted Therapy volume 9, Article number: 143 (2024) Cite this article 5732 Accesses 1 Altmetric Metrics details Abstract Metastatic pancreatic cancer (mPC) has a dismal prognosis. Herein, we conducted a prospective, multicentre, single-arm, phase II trial evaluating the ...
CD8+T cells increased whereas that of Treg cells decreased significantly, resulting in a significant increase in the ratio of CD8+T/Treg in the PD1-IL2v-treated tumors and lymph nodes, regardless of RT therapy. The expression of proteins related to CD8+T cell proliferation, function, ...
In addition, PD1 can promote fatty acid β oxidation of endogenous lipids in activated T cells by increasing CPT1A expression [9]. In 116 stage IV melanoma patients treated with anti-PD1 antibodies, the functional differences between the responding and non-responding groups are mainly related to ...
Immunotherapy has achieved notable success in tumor treatment, but it is restricted to a small number of patients due to multiple immunosuppressive pathways in the tumor microenvironment. Here, we present a step-by-step protocol to prepare functional cellular nanovesicles from HEK293-FT cells displayin...
Howard et al., Therapeutic Blockade of TCR Signal Transduction and Co-Stimulation in Autoimmune Disease, Current Drug Targets, 2005, pp. 85-94, vol. 4. Hufton et al., Development and application of cytotoxic T lymphocyte-associated antigen 4 as a protein scaffold for the generation of novel...
Agata, Y., “Expression of the PD-1 antigen on the surface of stimulated mouse T and B lymphocytes,” Int. Immunology, 8(5):765-772 (May 1996). Castelli, C., et al., “Lymphocyte activation gene-3 (LAG-3, CD223) in plasmacytoid dendritic cells (pDCs): a molecular target for ...