PD-1 signaling limits expression of phospholipid phosphatase 1 and promotes intratumoral CD8+ T cell ferroptosis Author links open overlay panelYu Ping 1 9, Jiqi Shan 1 9, Haiming Qin 1 2 9, Feng Li 1, Jiao Qu 1, Ru Guo 1, Dong Han 1, Wei Jing 1, Yaqing Liu 1, Jinyan Liu 1,...
examine phospholipid metabolismin the TME and f i nd an alteredphospholipid prof i le in intratumoral CD8 +T cells. These alterations result fromreduced expression of phospholipidphosphatase-1 downstream of PD-1signaling and lead to CD8 + T cellferroptosis and impaired antitumorfunction.Ping et al...
磷脂磷酸酶1(PLPP1)是一种调控磷脂代谢的关键酶,那在TME中PD-1与 PLPP1的表达是否相关,PLPP1能否调控磷脂代谢来损害CD8+ T细胞的功能,都值得深入探究。 本月,由郑州大学第一附属医院张毅教授带领的研究团队在《Immunity》杂志上发表了题为“PD-1 signaling limits expression of phospholipid phosphatase 1 and p...
Transcriptomic analysis and immune inference using single state deconvolution (Methods) revealed an increase in the overall immune cell expression at flare. Notably, transcriptome signaling revealed that activated CD8+ T cells were significantly increased in both samples following ICI (Fig. 6a,b and ...
Phenotypic and transcriptional profiling of regulatory T (Treg) cells at homeostasis reveals that T cell receptor activation promotes Treg cells with an effector phenotype (eTreg) characterized by the production of interleukin-10 and expression of the inhibitory receptor PD-1. At homeostasis, blockade...
In conclusion, we discovered that aspirin suppressed PD-L1 expression through suppressing KAT5 and subsequently inhibited PD-1 and PD-L1 signaling to attenuate OC development. Aspirin may be an effective therapeutic drug for immunotherapy of OC. Conflicts of Interest The authors declare that they hav...
Programmed cell death protein 1/programmed cell death ligand 1 (PD-1/PD-L1) is a negative modulatory signaling pathway for activation of T cell. It is acknowledged that PD-1/PD-L1 axis plays a crucial role in the progression of tumor by altering status o
PD-L1 expression is negatively correlated with the number of intra-epithelial infiltrating CD8+T cells, suggesting that the PD-L1 expression on tumor cells prevents CD8+T cells from infiltrating tumor sites [50]. These studies indicated that blocking PD-1 signaling might improve clinical outcomes ...
Another member of the JAK signaling pathway, JAK3, regulates PD-L1 expression in lymphomas (Green et al., 2012). The presence of somatic and germline activating mutations in JAK3 has been proposed as another mechanism that may be associated with increased PD-L1 expression on tumor cells and ...
However, the tumor-suppressive mechanisms of PD-1 signaling remain unknown. Here, using tractable mouse models for T-NHL and primary patient samples, we demonstrate that PD-1 signaling suppresses T cell malignancy by restricting glycolytic energy and acetyl coenzyme A (CoA) production. In addition...