Molecular dissection of NRG1-ERBB4 signaling implicates PTPRZ1 as a potential schizophrenia susceptibility gene. Mol Psychiatry. 2008; 13 :162–72. doi: 10.1038/sj.mp.4001991. [ Cross Ref ]Buxbaum JD, Georgieva L, Young JJ, Plescia C, Kajiwara Y, et al. (2008) Molecular dissection of ...
Reagents Antibodies used in this study were as follows: rabbit anti-phospho-ErbB4 (Cell Signaling Technologies, 1:1,000, western blotting), rabbit anti-phospho-ErbB4 (Abcam, 1:2,000, cell staining), rabbit anti-ErbB4 (Santa Cruz Biotechnology, 1:400), rabbit anti-NRG1 (Santa Cruz Biotec...
(a GABAA receptor inhibitor).NRG1-ErbB4 signaling inhibitor also attenuates GABAA receptor-mediated synaptic currents while its enhancer has no effect.Both thalamus and cortex input LTP can be induced in the LA after perfusion of Ecto-ErbB4, but no LTP in the normal conditions.Perfusion of ...
We found that blocking NRG1–ErbB4 signaling in the BLA enhanced anxiety-like behaviors and, concomitantly, inhibited GABA release. The high-anxiety mice expressed a low level of both NRG1 and ErbB4, specifically in the amygdala, and the administration of exogenous NRG1 reversed their anxiety ...
Objective: To investigate the alteration of PV interneurons in ALS mainly focusing its dynamic changes and its relationship with motor neurons and ErbB4 signaling. Methods: SOD1G93A mice were used as ALS model. ALS animals were divided into different groups according to birth age: symptomatic ...
MSC- ERBB4 not only significantly preserved heart functions accompanied with reduced infarct size and enhanced cardi- omyocyte division, but also improved MSC survival and created an autocrine loop in the NRG1-ERBB4-NRG1 signaling pathway. These results suggest that engineering ERBB4 in MSCs could...
Role of the NRG1/ErbB4 and PI3K/AKT/mTOR signaling pathways in the anti-psychotic effects of aripiprazole and sertindole in ketamine-induced schizophrenia... DA Nawwar,HF Zaki,RH Sayed - 《Inflammopharmacology》 被引量: 0发表: 2022年 Comparative efficacy and tolerability of 15 antipsychotic dru...
Neuregulin-1(NRG1)signaling through the tyrosine kinase receptors erbB2 and erbB4 is required for cardiac morphogenesis,and it plays an essential role in m... C Vasti,Cecilia M Hertig - 世界心脏病学杂志(电子版)(英文版) 被引量: 22发表: 2014年 Paracrine Effect of NRG1 and HGF Drives Resi...
Moreover, using an in vitro neuronal culture system, we found that NRG1-ErbB4 signaling protects neurons from glutamate-induced death, and such protective effects could be diminished by GABA receptor antagonist. These results indicate that NRG-ErbB4 signaling protects cortical neurons from TBI-...
Neurgulin 1 (NRG1) - ErbB4 signaling as a target for the treatment of schizophreniaThis invention relates to methods and compositions for the treatment of schizophrenia. Specifically, provided herein are methods and compositions for the treatment of schizophrenia by modulating the effect of Neuregulin...