In addition, NRG1-ErbB4 signaling suppressed phosphorylation of GluN2B at position 1472 by Src kinase, and decreased levels of phosphorylation level of GluN2B and Src were detected in human symptomatic epilepsy tissues. Our study revealed a critical role of the NRG1-ErbB4 signaling pathway in ...
Reagents Antibodies used in this study were as follows: rabbit anti-phospho-ErbB4 (Cell Signaling Technologies, 1:1,000, western blotting), rabbit anti-phospho-ErbB4 (Abcam, 1:2,000, cell staining), rabbit anti-ErbB4 (Santa Cruz Biotechnology, 1:400), rabbit anti-NRG1 (Santa Cruz Biotec...
(a GABAA receptor inhibitor).NRG1-ErbB4 signaling inhibitor also attenuates GABAA receptor-mediated synaptic currents while its enhancer has no effect.Both thalamus and cortex input LTP can be induced in the LA after perfusion of Ecto-ErbB4, but no LTP in the normal conditions.Perfusion of ...
α-humulene ; dizocilpine maleate (MK801) ; schizophrenia ; NRG1/ErbB4 signaling pathway ; NO [Abstract] Objective To study the treating mechanism of α-humulene on the schizophrenic mice. Methods The schizophrenic models were established by dizocilpine maleate (MK801), then different concentrati...
Neuregulin-1/ErbB4 Signaling Regulates Visual Cortical Plasticity Summary Experience alters cortical networks through neural plasticity mechanisms. During a developmental critical period, the most dramatic consequence of ... Yanjun,Sun,Taruna,... - 《Neuron》 被引量: 24发表: 2016年 Neuregulin-1 signal...
Role of the NRG1/ErbB4 and PI3K/AKT/mTOR signaling pathways in the anti-psychotic effects of aripiprazole and sertindole in ketamine-induced schizophrenia... DA Nawwar,HF Zaki,RH Sayed - 《Inflammopharmacology》 被引量: 0发表: 2022年 Comparative efficacy and tolerability of 15 antipsychotic dru...
This study demonstrates that ginsenoside Rd (G-Rd) upregulates NRG1/ErbB4 signaling to protect against cerebral ischemia/reperfusion injury (CIRI). • This study demonstrates that G-Rd exerts blood-brain barrier (BBB) protection by inhibiting endothelial ferroptosis. • Mechanistically, G-Rd up...
(2008). Molecular dissection of NRG1-ERBB4 signaling implicates PTPRZ1 as a potential schizophrenia susceptibility gene. Molecular Psychiatry 13, 162-172.Buxbaum, J. D., Georgieva, L., Young, J. J., Plescia, C., Kajiwara, Y., Jiang, Y. (2008) Molecular dissection of NRG1-ERBB4 ...
Moreover, using an in vitro neuronal culture system, we found that NRG1-ErbB4 signaling protects neurons from glutamate-induced death, and such protective effects could be diminished by GABA receptor antagonist. These results indicate that NRG-ErbB4 signaling protects cortical neurons from TBI-...
Neurgulin 1 (NRG1) - ErbB4 signaling as a target for the treatment of schizophreniaThis invention relates to methods and compositions for the treatment of schizophrenia. Specifically, provided herein are methods and compositions for the treatment of schizophrenia by modulating the effect of Neuregulin...