The presynaptic protein neuregulin1 (NRG1) is cleaved by beta-site APP cleaving enzyme 1 (BACE1) in a similar way as amyloid precursor protein (APP) NRG1 can activate post-synaptic receptor tyrosine-protein kinase erbB4 (ErbB4) and was linked to schizophrenia. The NRG1/ErbB4 complex is ne...
Compared with ERBB2 and ERBB3, ERBB1 and ERBB4 were most abundant in interstitial and tubular somatic cells, respectively (Figure 1b). A relatively weak ERBB4 band was detected in freshly isolated type A spermatogonia, but not in the rat spermatogonial line (Figure 1b). Erbb-family ...