(2006) provide evidence for direct signaling in the nucleus by an intracellular ErbB4 receptor fragment that is released upon receptor activation by ligand. The fragment forms a complex with the adaptor TAB2 and the corepressor N-CoR and transits to the nucleus, where it represses transcription ...
Phosphorylated YAP (Ser127) polyclonal antibody Cell Signaling Cat# 4911; RRID: AB_2218913 LATS1 rabbit monoclonal antibody Cell Signaling Cat# 3477; RRID: AB_2133513 MST2 rabbit polyclonal antibody Cell Signaling Cat# 3952; RRID: AB_2196471 TALIN mouse monoclonal antibody Sigma Cat# T3287; RRID...
Besides that, NF-κB signaling in BC cells modulated by flavonoids has also involved the regulation of ATP-binding cassette transporters, apoptosis, autophagy, cell cycle, and changes in the activity of cancer stem cells, oncogenes, or controlling of gene repair. The evaluation of conventional ...
These results support the presence of signaling interaction between the NRF2 and HER4 receptor pathways and suggest that intervention modulating this cross-talk could have anticancer therapeutic value. Keywords Cancer, ovarian, nuclear factor erythroid 2-related factor 2, HER4-receptor, regulation, rexin...
In the nucleus, genomic DNA is wrapped around histone octamers to form nucleosomes. In principle, nucleosomes are substantial barriers to transcriptional activities. Nuclear non-coding RNAs (ncRNAs) are proposed to function in chromatin conformation modu
Moreover, the mitogen-activated protein-kinase kinase (MAPKK, MEK)/extracellular signal-regulated kinase (ERK) pathway is a key downstream mediator of EGF signaling, and inhibition of MEK/ERK with U0126 effectively abrogated the above protein translocation (Fig. 1F, bottom panel). This result ...
Nuclear calcium signaling controls CREB-mediated gene expression triggered by synaptic activity. Nat. Neurosci. 4, 261–267 (2001). Article CAS Google Scholar Rodrigues, M.A. et al. Nucleoplasmic calcium is required for cell proliferation. J. Biol. Chem. 282, 17061–17068 (2007). Article ...
Thus, the consequence of E2 signaling in NB is the opposite to the well-known oncogenic effect in breast cancer [61, 62]. In NB, ERα overexpression is partly sufficient to overcome the malignant phenotype associated with MYCN overexpression supported by increased levels of differentiation markers...
Rabbit monoclonal anti-phospho-Histone H2A.X antibody (Ser139) (20E3) Cell Signaling Cat# 9718; RRID: AB_2118009 Rabbit monoclonal anti-Nucleolin antibody (D4C7O) Cell Signaling Cat# 14574; RRID: AB_2798519 Rabbit monoclonal anti-Histone H2B antibody (D2H6) Cell Signaling Cat# 12364; RRID:...
Network analysis of the relationship between FAK-dependent chemokine ligand expression in SCC cells and tumor-infiltrating Treg chemokine receptor expression revealed the existence of a FAK-dependent paracrine signaling axis between cancer cells and intra-tumoral Tregs based on chemokine ligand-receptor ...