Presenilin-dependent ErbB4 nuclear signaling regulates the timing of astrogenesis in the developing brain. Cell 2006;127(1):185–97.Sardi SP, Murtie J, Koirala S, Patten BA, Corfas G. Cell. 2006; 127 :185–197. [ PubMed ]Sardi S. P., Murtie J., Koirala S., Patten B. A., ...
The intracellular portion of c-Met consists of a juxtamembrane domain that harbors regulatory motifs,2–4 a tyrosine kinase domain that has tyrosine kinase activity and a C-terminal domain that contains a multifunctional docking site for various signaling molecules. Upon binding with HGF, c-Met ...
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These results support the presence of signaling interaction between the NRF2 and HER4 receptor pathways and suggest that intervention modulating this cross-talk could have anticancer therapeutic value. Keywords Cancer, ovarian, nuclear factor erythroid 2-related factor 2, HER4-receptor, regulation, rexin...
mutagenesisof these sequences results in impairedtransactivationin the setting of normal hormone binding and heterodimerization withRXR[115]. SRC-1 has also been shown to enhance the ligand-dependent interaction between Smad-3, a protein involved in the transforming growth factor-βsignaling pathway, ...
The growth of human breast tumor cells is regulated through signaling involving cell surface growth factor receptors and nuclear receptors of the steroid/t... O Afonja,D Juste,S Das,... - 《Oncogene》 被引量: 414发表: 2004年 c-erbB-2 oncogene related to p53 expression, cell proliferation ...
Thus, the consequence of E2 signaling in NB is the opposite to the well-known oncogenic effect in breast cancer [61, 62]. In NB, ERα overexpression is partly sufficient to overcome the malignant phenotype associated with MYCN overexpression supported by increased levels of differentiation markers...
These findings are in agreement with our previous report that E2-induced tumor regression is accompanied by downregulation of AKT signaling in this model[9]. To our knowledge this is the first study to report an association of extranuclear ERα with tumor regression, as opposed to the ...
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