Pertuzumab, a novel dimerization inhibitor, inhibits the growth of human lung cancer cells mediated by the HER3 signaling pathway. Cancer Sci. 98, 1498–1503 (2007). Article CAS PubMed Google Scholar Mann, M. et al. Targeting cyclooxygenase 2 and HER-2/neu pathways inhibits colorectal ...
Sredni S, Patel K, Costa F, de Fatima Bonaldo M, Tomita T. Activation of ErbB2- ErbB3 signaling pathway supports potential therapeutic activity of ErbB inhibitors in AT/RT. J Neurooncol. 2014;118(1):201-203.Sredni ST, Patel K, D'Almeida Costa F, de Fatima Bonaldo M, Tomita T, ...
In contrast, ErbB2 exhibits a different structure because it has an extended conformation in the absence of ligands, with its domain 2 loop available for interaction 1Division of Pathogenetic Signaling, Department of Biochemistry and Molecular Biology, Kobe University Graduate School of Medicine, 1-5...
mutantofErbB2.However,asopposedtoER,thep38MAPKpathwaywasfoundtobeinvolvedinligandedER repressionactivitybyErbB2 signalingandinregulatingestrogen-responsivepromoteroccupancybyER .TherepressioninER responsetohormonewasdependentupon itsAF-1domainwhichincludesserines106and124,twophosphorylationtargetsitesforErkthatwepreviou...
Myocilin signaling through ErbB2/3 receptors may contribute to these observed effects. Myocilin binds to ErbB2/ErbB3, activates these receptors, and affects the downstream PI3K-AKT signaling pathway. These data implicate a role for myocilin in the development and/or maintenance of myelination and ...
通路(Pathway) JAK/STAT--EGFR 分子式(Formula) C23H25ClFN5O3 分子量(Molecular Weight) 473.93 外观(Appearance) 粉末 纯度(Purity) ≥98% 溶解性(Solubility) 溶于DMSO 结构式(Structure) 细胞实验(体外实验) 在KB细胞中,AZD8931抑制配体刺激的EGFR磷酸化。AZD8931还抑制MCF-7细胞和MCF-7cl24细胞中erbB2和er...
HER2 signaling pathway activation and response of breast cancer cells to HER2-targeting agents is dependent strongly on the 3D microenvironment. Breast Cancer Res Treat 2010; 122: 35–43. Article CAS PubMed Google Scholar Reim F, Dombrowski Y, Ritter C, Buttmann M, Hausler S, Ossadnik M ...
miR-199a regulates the PI3K/Akt and ERK/MAPK signaling pathways, the oxidative stress signaling pathway, and prostaglandin synthesis (26). Two mature miRNA products, miR-199a-5p and miR-199a-3p, are expressed from the miR-199a precursors that map to chromosome 19 (miR-199a-1) and chromo...
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Ovarian cancer cell metastasis is induced by signaling pathway activated by the binding of type IV collagen to β1 integrin receptor on the surface of cancer cells and estrogen binding to estrogen receptor. However, the role of estradiol-17β and type IV collagen on the development of ovarian ...