However, the signaling pathways that induce termination of pro-inflammatory macrophages are incompletely defined. We tested whether the ErbB4 receptor tyrosine kinase, previously not known to have role in macrophage biology, is involved in this process., pro-inflammatory activation of cultured murine ...
Together, these findings identify a previously unknown signaling pathway in the PL cortex that regulates fear expression. As both NRG1 and ErbB4 are risk genes for schizophrenia, our study may shed new light on the pathophysiology of this disorder and help to improve treatments for psychiatric ...
the accumulation of 4ICD and cytochrome c efflux, and directly couples a cell surface signal to the tumor cell mitochondrial apoptotic pathway. Accordingly, in contrast to the other three members of the EGFR family, ErbB4 expression seems to be selectively lost in tumors with aggressive phenotypes...
技术支持 货号14-9687-80 Price (CNY) 2,683.00 下单后预计有货时间 20-Jun-2025 查看价格 批量或定制请求 Application Created with Sketch. 图:1/1 ErbB4 (Her4) Antibody (14-9687-80) in IHC (P) Immunohistochemistry of formalin-fixed paraffin embedded human infiltrating ductal carcinoma using 10 ...
However, blocking We found, for the first time to our knowledge, that the the NRG1–ErbB4 signaling pathway of the BLA either with NRG1–ErbB4 signaling in the amygdala was critical for ecto-ErbB4, AG1478, or PD, or knocking down the ErbB4 modulating anxiety-like behaviors through GABA...
It has been shown that the ligand-indued proteolytic process of ErbB4 results in the accumulation of 4ICD and cytochrome c efflux, and directly couples a cell surface signal to the tumor cell mitochondrial apoptotic pathway. Accordingly, in contrast to the other three members of the EGFR ...
[34]58 Hahn C G, Wang H Y, Cho D S, et al. Altered neuregulin 1-erbB4 signaling contributes to NMDA receptor hypofunction in schizophrenia. Nat Med, 2006, 12: 824-828 [35]59 Pitcher G M, Kalia L V, Ng D, et al. Schizophrenia susceptibility pathway neuregulin 1-ErbB4 suppresses ...
Moreover, in the brain of ALS transgenic mice, we also observed impairment in the ErbB4 proteolytic processing rate, indicative of failure in this signaling pathway. Access through your organization Check access to the full text by signing in through your organization. Access through your ...
We speculate that ErbB4 is an upstream regulator of TTF-1 and regulates Sftpb expression via this pathway in alveolar type II cells. Neuregulin-induced ErbB4 and TTF-1 signaling interactions were studied by co-immunoprecipitation and confocal microscopy. Overexpression of ErbB4 and TTF-1 was ...
signaling positive regulation of phosphatidylinositol 3-kinase signaling cell migration peptidyl-tyrosine phosphorylation central nervous system morphogenesis olfactory bulb interneuron differentiation regulation of cell migration ERBB2 signaling pathway positive regulation of tyrosine phosphorylation of Stat5 protein ...