The importance of the ErbB signaling axis to cancer is illustrated by the number of articles and reviews published on this topic to date (>20,000 and >3000, respectively). In line with the importance of ErbB signaling to cancer, several anticancer therapies have been developed targeting various...
ErbB signaling involves many pathways including Akt and MAPK. Use the interactive pathway map to find related RayBiotech products.
et al. Oncogenic activation of the RAS/RAF signaling pathway impairs the response of metastatic colorectal cancers to anti-epidermal growth factor receptor antibody therapies. Cancer Res. 67, 2643–2648 (2007). Article CAS PubMed Google Scholar Di Fiore, F. et al. Clinical relevance of KRAS ...
Pertuzumab, a novel dimerization inhibitor, inhibits the growth of human lung cancer cells mediated by the HER3 signaling pathway. Cancer Sci. 98, 1498–1503 (2007). Article CAS PubMed Google Scholar Mann, M. et al. Targeting cyclooxygenase 2 and HER-2/neu pathways inhibits colorectal ...
Curcumin inhibits cell proliferation and induces apoptosis of human non-small cell lung cancer cells through the upregulation of miR-192-5p and suppression of PI3K/Akt signaling pathway[J]. Oncol Rep, 2015,34(5):2782-2789. DOI: 10.3892/or.2015.4258 . 返回引文位置Google Scholar 百度学术 万方...
2017. ErbB 信号通路及其对胆囊癌靶向治疗的 研究进展 [J]. 中国肿瘤生物治疗杂志, 24(04): 447- 452. (Zhou Y, Tan J. 2017. ErbB signaling pathway and its targeted therapy in gallbladder cancer[J]. Chinese Journal of Cancer Biotherapy, 24(04): 447-452. )周勇.ErbB信号通路及其对胆囊癌靶向...
Our previous genomic whole-exome sequencing (WES) data identified the key ErbB pathway mutations that play an essential role in regulating the malignancy of gallbladder cancer (GBC). Herein, we tested the hypothesis that individual cellular components of the tumor microenvironment (TME) in GBC func...
Cancer Immunoediting CCR5 Pathway in Macrophages CD4 and CD8 T-Cell Lineage Cell Cycle & Proliferation Pathways Intrinsic and Extrinsic Pathways of Apoptosis CTLA4 Signaling Pathway Killer T Cell Mediated Apoptosis Pathway Cytokine Pathways | Growth Factor Pathways...
ErbB-2 via PYK2 upregulates the adhesive ability of androgen receptor-positive human prostate cancer cells.Yuan TC, Lin FF, Veeramani S, Chen SJ, Earp HS 3rd, Lin MF. Oncogene.2007 Nov 29;26(54):7552-9.Epub 2007 Jun 11. Nrg1/ErbB signaling networks ...
Nature Reviews Cancer volume 13, pages 663–673 (2013)Cite this article 21k Accesses 8 Altmetric Metrics details Abstract The ERBB family of receptor tyrosine kinases has a central role in the tumorigenesis of many types of solid tumour. Various therapeutics targeting these receptors have been ...