《NRG1/ErbB4通路介导Cornelia de Lange 综合征小鼠认知障碍的研究》是依托浙江大学，由黄寿奖担任项目负责人的青年科学基金项目。项目摘要 Cornelia de Lange 综合征(CdLS)是一种伴有严重认知障碍的遗传性疾病。但是其认知障碍的具体发病机制仍然不明。本项目组前期研究发现CdLS小鼠模型海马NRG1...
Molecular dissection of NRG1-ERBB4 signaling implicates PTPRZ1 as a potential schizophrenia susceptibility gene. Mol Psychiatry. 2008; 13 :162–72. doi: 10.1038/sj.mp.4001991. [ Cross Ref ]Buxbaum JD, Georgieva L, Young JJ, Plescia C, Kajiwara Y, et al. (2008) Molecular dissection of ...
维持正常认知功能.ErbB4受体异常可致PV和谷氨酸脱羧酶67(glutamic acid decarboxylase 67, GAD67)表达水平显著下降.因此,我们推测NRGl-ErbB4信号通路异常是异氟醚吸入诱导老年小鼠认知功能损伤的机制之一.本研究探讨海马NRG1-ErbB4信号通路在异氟醚吸入诱导老年小鼠认知功能损伤中的作用,并观察海马PV和GAD67的表达变化...
Neuregulin-1 (NRG1) and its receptor ErbB4 influence several processes of neurodevelopment, but the mechanisms regulating this signalling in the mature brain are not well known. DISC1 is a multifunctional scaffold protein that mediates many cellular proc
本研究旨在探究抗精神病药慢性给药对大鼠前额叶与海马内神经生长因子1(NRG1)及其受体ErbB2、ErbB3和ErbB4表达的影响。 研究使用大鼠模型,将大鼠随机分为两组,一组接受抗精神病药物慢性给药,另一组接受安慰剂慢性给药作为对照。给药周期为4周,每周3次,每次给药后观察大鼠的行为表现。在给药结束后,大鼠被处死,...
Anxiety disorder is related to the pathophysiology of psychiatric diseases, including major depression, substance abuse, and schizophrenia. The amygdala is important for manifestation and modulation of anxiety. However, relatively little is known regardi
本文主要从以下几方面展开论述: 第一部分:CK2缺失介导抑郁症NRG1-ErbB4通路紊乱机制研究 背景: 抑郁症是一类心境障碍的统称,它的主要临床特征为显著而持久的心境低落,记忆认知障碍,思维缓慢,快感缺失和一些躯体症状.它的发病机制主要集中在神经回路,单胺类神经递质,神经内分泌与神经免疫功能,遗传因素与表观遗传学机制...
目的探讨氯胺酮连续给药致小鼠产生的类似精神分裂症症状,与精神分裂症易感基因神经调节蛋白1(neuregulin-1,NRG1)及其受体ErbB4 mRNA表达的相关性,为研究精神分裂症的可能发病机制提供参考依据。方法50只雄性昆明种小鼠,随机分为生理盐水组、氯胺酮小剂量(25 mg/kg)、中剂量(50 mg/kg)、大剂量(100 mg/kg)组和氯...
NRG1, MSCs or MSC-ERBB4 (MSC with ERBB4 overexpression), were transplanted into mice following myocardial infarction. Superior to that of MSCs and solely NRG1, MSC-ERBB4 transplantation significantly preserved heart functions accompanied with reduced infarct size, enhanced cardiomyocyte division and ...