Neratinib: An irreversible pan-HER inhibitor that can inhibit ERBB1, ERBB2, and ERBB4 signaling pathways, and is theoretically also useful in treating NRG1 fusion tumors. 5. Immunotherapy Combinations Some studies are exploring the use of PD-1/PD-L1 immune checkpoint inhibitors in combination wit...
However, the exact roles and mechanism for NRG1/ErbB4 in human symptomatic epilepsy are still unclear. Using fresh human symptomatic epilepsy tissues, we found that the protein levels of NRG1 and ErbB4 were significantly increased in the temporal cortex. In addition, NRG1-ErbB4 signaling ...
[9] Fock, Valerie, et al. "Neuregulin-1-mediated ErbB2-ErbB3 signalling protects human trophoblasts against apoptosis to preserve differentiation." Journal of cell science 128.23 (2015): 4306-4316.[10] Wadugu, Brian, and Bernhard Kühn. "The role of neuregulin/ErbB2/ErbB4 signaling in t...
"The role of neuregulin/ErbB2/ErbB4 signaling in the heart with special focus on effects on cardiomyocyte proliferation." American Journal of Physiology-Heart and Circulatory Physiology 302.11 (2012): H2139-H2147.[11] Dimou, Anastasios, and D. Ross Camidge. "Detection of NRG1 fusions in ...
These results suggest exercise may regulate adult neurogenesis and PV neuron activity through ErbB4 signaling. Overall, these findings provide further evidence of the importance of exercise for neurogenesis and suggest that targeting ErbB4 may be a promising strategy for improving memory and other ...
Neuregulin-1 (NRG1) and its receptor ErbB4 influence several processes of neurodevelopment, but the mechanisms regulating this signalling in the mature brain are not well known. DISC1 is a multifunctional scaffold protein that mediates many cellular proc
.NRG1-ErbB4 signaling inhibitor also attenuates GABAA receptor-mediated synaptic currents while its enhancer has no effect.Both thalamus and cortex input LTP can be induced in the LA after perfusion of Ecto-ErbB4, but no LTP in the normal conditions.Perfusion of ecto-ErbB4 can not further ...
除阿法替尼以外,治疗NRG1融合驱动的实体瘤患者病例报告或篮子试验中研究的药物包括抗ErbB3药物Lumretuzumab(两名SD持续4个月的患者)和双特异性人源化单克隆抗体Zenocutuzumab(MCLA-128)(三名患者持续治疗:一例PR达7个月,一例PR达4.5个月和一例SD达7个月;目前该药处于临床I/II期试验)。此外,针对NRG1融合...
Effects of icariin on NRG1-ErbB signaling pathways in hippocampus of schizophrenia rats Liu Yunqin1, Lin Li2, Xiao Wenhao1, Ji Qiuming1, Liu Yanqin3 摘要: 文题释义: 精神分裂症:是一种严重的慢性精神疾患,主要致病原因有大脑结构异常、遗传因素、妊娠分娩、环境因素等,患者主要表现为感知觉、情感和行...
结论α-葎草烯通过下调NRG1/ErbB4信号通路,改善精神分裂症小鼠异常行为,从而达到治疗精神分裂症的目的。 [Key word] α-humulene ; dizocilpine maleate (MK801) ; schizophrenia ; NRG1/ErbB4 signaling pathway ; NO [Abstract] Objective To study the treating mechanism of α-humulene on the schizophrenic...