Neratinib: An irreversible pan-HER inhibitor that can inhibit ERBB1, ERBB2, and ERBB4 signaling pathways, and is theoretically also useful in treating NRG1 fusion tumors. 5. Immunotherapy Combinations Some studies are exploring the use of PD-1/PD-L1 immune checkpoint inhibitors in combination wit...
[9] Fock, Valerie, et al. "Neuregulin-1-mediated ErbB2-ErbB3 signalling protects human trophoblasts against apoptosis to preserve differentiation." Journal of cell science 128.23 (2015): 4306-4316.[10] Wadugu, Brian, and Bernhard Kühn. "The role of neuregulin/ErbB2/ErbB4 signaling in t...
Our study suggested that the CSF-contacting nucleus plays a regulatory role in thermal pain in mice via NRG1-ErbB4 signaling.doi:10.1016/j.neuroscience.2024.12.052Yuhan DingYao YanWei SongYing LiJing ZhaoBin GuiYijun ZhangLicai ZhangElsevier Inc.Neuroscience...
"The role of neuregulin/ErbB2/ErbB4 signaling in the heart with special focus on effects on cardiomyocyte proliferation." American Journal of Physiology-Heart and Circulatory Physiology 302.11 (2012): H2139-H2147.[11] Dimou, Anastasios, and D. Ross Camidge. "Detection of NRG1 fusions in ...
Neuregulin-1 (NRG1) and its receptor ErbB4 influence several processes of neurodevelopment, but the mechanisms regulating this signalling in the mature brain are not well known. DISC1 is a multifunctional scaffold protein that mediates many cellular proc
除阿法替尼以外,治疗NRG1融合驱动的实体瘤患者病例报告或篮子试验中研究的药物包括抗ErbB3药物Lumretuzumab(两名SD持续4个月的患者)和双特异性人源化单克隆抗体Zenocutuzumab(MCLA-128)(三名患者持续治疗:一例PR达7个月,一例PR达4.5个月和一例SD达7个月;目前该药处于临床I/II期试验)。此外,针对NRG1融合...
Neuregulin is a signaling protein for ErbB2/ErbB4 receptor heterodimers on the cardiac muscle cells, playing an important role in heart structure and function through inducing ErbB2/ErbB4 receptor phosphorylation and cardiomyocyte differentiation. Research on molecular level discovered that recombinant neure...
Effects of icariin on NRG1-ErbB signaling pathways in hippocampus of schizophrenia rats Liu Yunqin1, Lin Li2, Xiao Wenhao1, Ji Qiuming1, Liu Yanqin3 摘要: 文题释义: 精神分裂症:是一种严重的慢性精神疾患,主要致病原因有大脑结构异常、遗传因素、妊娠分娩、环境因素等,患者主要表现为感知觉、情感和行...
NRG1/ErbB4通路是神经调节素与其ErbB受体组成的一条在细胞的增殖分化、心血管以及神经系统发育等生命过程中起着关键作用的神经信号传导通路,与精神分裂症、阿尔茨海默病、癫痫、多发性硬化等脑血管疾病,心力衰竭、心肌梗死、动脉粥样硬化等心血管疾病以及癌症等密切相关,尤其在促进心脏发育和心肌细胞的生长繁殖、维持心肌...
Disrupted neuregulin 1-ErbB4 signaling: Consequences of prenatal morphine exposure in rat pups and molecular gateway to neurological impairment Article 作者: Fanaei, Hamed ; Ghanbarzehi, Abdolhakim ; Hafezinouri, Hamid ; Mirzaei, Ilia ; Khayat, Samira ; Parsi-Moud, Abolfazl ObjectiveMorphine expo...