Our study suggested that the CSF-contacting nucleus plays a regulatory role in thermal pain in mice via NRG1-ErbB4 signaling.doi:10.1016/j.neuroscience.2024.12.052Yuhan DingYao YanWei SongYing LiJing ZhaoBin GuiYijun ZhangLicai ZhangElsevier Inc.Neuroscience
Neratinib: An irreversible pan-HER inhibitor that can inhibit ERBB1, ERBB2, and ERBB4 signaling pathways, and is theoretically also useful in treating NRG1 fusion tumors. 5. Immunotherapy Combinations Some studies are exploring the use of PD-1/PD-L1 immune checkpoint inhibitors in combination wit...
10. DISC1 is also reportedly expressed in interneurons24,25, and we confirmed its expression in PV-positive interneurons in the cortex (Supplementary Fig. 1a). We therefore hypothesized that DISC1 may influence NRG1-ErbB4 signalling via association with the PSD...
[9] Fock, Valerie, et al. "Neuregulin-1-mediated ErbB2-ErbB3 signalling protects human trophoblasts against apoptosis to preserve differentiation." Journal of cell science 128.23 (2015): 4306-4316.[10] Wadugu, Brian, and Bernhard Kühn. "The role of neuregulin/ErbB2/ErbB4 signaling in t...
"The role of neuregulin/ErbB2/ErbB4 signaling in the heart with special focus on effects on cardiomyocyte proliferation." American Journal of Physiology-Heart and Circulatory Physiology 302.11 (2012): H2139-H2147.[11] Dimou, Anastasios, and D. Ross Camidge. "Detection of NRG1 fusions in ...
Effects of icariin on NRG1-ErbB signaling pathways in hippocampus of schizophrenia rats 摘要: 文题释义: 精神分裂症:是一种严重的慢性精神疾患,主要致病原因有大脑结构异常、遗传因素、妊娠分娩、环境因素等,患者主要表现为感知觉、情感和行为的异常,一般多并发精神衰退、精神残疾等疾病。大部分患者患病年龄为15-...
MSC- ERBB4 not only significantly preserved heart functions accompanied with reduced infarct size and enhanced cardi- omyocyte division, but also improved MSC survival and created an autocrine loop in the NRG1-ERBB4-NRG1 signaling pathway. These results suggest that engineering ERBB4 in MSCs could...
除阿法替尼以外,治疗NRG1融合驱动的实体瘤患者病例报告或篮子试验中研究的药物包括抗ErbB3药物Lumretuzumab(两名SD持续4个月的患者)和双特异性人源化单克隆抗体Zenocutuzumab(MCLA-128)(三名患者持续治疗:一例PR达7个月,一例PR达4.5个月和一例SD达7个月;目前该药处于临床I/II期试验)。此外,针对NRG1融合...
Neuregulin is a signaling protein for ErbB2/ErbB4 receptor heterodimers on the cardiac muscle cells, playing an important role in heart structure and function through inducing ErbB2/ErbB4 receptor phosphorylation and cardiomyocyte differentiation. Research on molecular level discovered that recombinant neure...
Disrupted neuregulin 1-ErbB4 signaling: Consequences of prenatal morphine exposure in rat pups and molecular gateway to neurological impairment Article 作者: Fanaei, Hamed ; Ghanbarzehi, Abdolhakim ; Hafezinouri, Hamid ; Mirzaei, Ilia ; Khayat, Samira ; Parsi-Moud, Abolfazl ObjectiveMorphine expo...