ncRNA为蛋白质编码的RNA分子,而是在细胞内执行其他功能。ncRNA基因有许多类型,其中一些包括: 转移RNA(tRNA):tRNA负责在蛋白质合成过程中将氨基酸带到核糖体上。有20种不同的tRNA基因,每种基因都编码一种特定的氨基酸。 核糖体RNA(rRNA):rRNA是核糖体的主要组成部分,是负责合成蛋白质的细胞机器。有几种不同类型的rR...
1.和siRNA一样装载成RISC(RNA induced silencing complex , RISC;沉默复合物)后互补配对的mRNA降解; 2.miRNA可抑制mRNA的翻译,降低靶基因的蛋白质水平但不影响期mRNA的水平。 三、lncRNA(long non-coding RNA) IncRNA的长度一般大于200bp。根据基因组位点或相关的DNA特征,可以进一步进行分类(图4): 图4 长链非...
A mutation was found in a noncoding RNA gene that the authors predicted would confer resistance to the antibiotic clindamycin, a lincosamide drug commonly administered in combination with quinine to treat pregnant women and infants for malaria in Peru. Reemerging strain resists antibiotics Sato et al...
Noncoding RNAs, by definition, do not become translated into protein. This broad category includes cellular RNAs that range in size from 20 to 20,000 nucleotides, can contain chemical modifications, adopt a wide variety of secondary and tertiary structures, associate with proteins and other RNA ...
Non-coding RNA Researchaims to publish high quality research and review articles on the mechanistic role of non-coding RNAs in all human diseases. This interdisciplinary journal will welcome research dealing with all aspects of non-coding RNAs-their biogenesis, regulation and role in disease … ...
1、微小RNA(microRNA, miRNA) miRNA是短ncRNA,约为22～23个核苷酸,其编码基因由RNA多聚酶Ⅱ转录,通过与mRNA 3′端非翻译区(3′ untranslated region, 3′UTR)之间的结合调控mRNA的表达,超过60%的编码基因是miRNA的潜在调控靶点。 2、长链非编码RNA(long non-coding RNA, lncRNA) ...
non-coding rna名词解释non-coding rna名词解释 非编码RNA(non-coding RNA,ncRNA)指的是在转录成RNA时不被翻译成蛋白质的RNA分子。与编码蛋白质的mRNA相比,ncRNA的功能非常多样,包括调控基因表达、RNA的剪接和稳定性、染色体转录后修饰等。非编码RNA是生物学研究领域中的一个热门话题,对于揭示细胞及多细胞生命现象的...
circRNA是一类以共价封闭环为特征,广泛存在于真核生物中的新型RNA分子。CircRNA来源于基因的外显子或者内含子区域,在哺乳动物细胞中大量存在。现有研究表明大部分的circRNA在不同物种间是保守的。同时,由于其环状结构能抵抗RNase R的降解而比较稳定。circRNA由于其表达的特异性和调控的复杂性,以及在疾病发生中的...
Previously, we have shown that a cluster of non-coding RNAs,() formed RNA cloud and upregulated thegene in the nuclei of LTED cells.were inhibited by resveratrol through ER. Here we prepared another polyphenol, glyceollin I from stressed soybeans, and identified it as a major inhibitor of...
然而,lncRNA在大小上存在显著差异,==长度超过10 kb的lncRNA属于超长基因间RNA (very long intergenic RNAs, vlinc)和宏观lncRNA==。这些转录本具有一些区别于其他lncRNA的特征:它们的剪接性差或不剪接,在3 '端弱聚腺苷酸化,并且由特定的基因组位点产生。大多数vlincRNA都位于同一条或相反的链上的PCG(蛋白编码...