Non-coding RNAs (ncRNAs) are ribonucleic acid (RNA) molecules that are not translated into protein products. Different classes of non-coding RNAs participate in different cellular processes; for example, gene e
1.和siRNA一样装载成RISC(RNA induced silencing complex , RISC;沉默复合物)后互补配对的mRNA降解; 2.miRNA可抑制mRNA的翻译,降低靶基因的蛋白质水平但不影响期mRNA的水平。 三、lncRNA(long non-coding RNA) IncRNA的长度一般大于200bp。根据基因组位点或相关的DNA特征,可以进一步进行分类(图4): 图4 长链非...
Conserved long noncoding RNAs transcriptionally regulated by Oct4 and Nanog modulate pluripotency in mouse embryonic stem cells. RNA 16, 324–337 (2010). Article PubMed PubMed Central CAS Google Scholar Loewer, S. et al. Large intergenic non-coding RNA-RoR modulates reprogramming of human ...
ncRNA为蛋白质编码的RNA分子,而是在细胞内执行其他功能。ncRNA基因有许多类型,其中一些包括: 转移RNA(tRNA):tRNA负责在蛋白质合成过程中将氨基酸带到核糖体上。有20种不同的tRNA基因,每种基因都编码一种特…
Non-Coding RNA Eukaryotic genomes are widely transcribed, but the vast majority of transcripts do not encode proteins. Classical examples ofnon-coding RNAsinclude ribosomal RNAs and tRNAs, which represent 90% and 15% of the totalRNAcontent of a typicalmammalian cell, respectively. Additional types ...
Non-coding RNA Researchaims to publish high quality research and review articles on the mechanistic role of non-coding RNAs in all human diseases. This interdisciplinary journal will welcome research dealing with all aspects of non-coding RNAs-their biogenesis, regulation and role in disease … ...
Non-codingRNA:Versatilityinformandfunction NoncodingRNAgenesaresurprisinglynumerous.NoncodingRNAhaveaverydifferentfunctions.TimeforRNomics Cell,89:669–672,May30,1997 PNAS,97(26):14035-14037,Dec19,2000 UnderstandingRNomicsfromanexpendingsnoRNAworld CouzinJ.Breakthroughoftheyear.SmallRNAsmakebigsplash.Science...
Noncoding RNAs, by definition, do not become translated into protein. This broad category includes cellular RNAs that range in size from 20 to 20,000 nucleotides, can contain chemical modifications, adopt a wide variety of secondary and tertiary structures, associate with proteins and other RNA ...
circRNA是一类以共价封闭环为特征,广泛存在于真核生物中的新型RNA分子。CircRNA来源于基因的外显子或者内含子区域,在哺乳动物细胞中大量存在。现有研究表明大部分的circRNA在不同物种间是保守的。同时,由于其环状结构能抵抗RNase R的降解而比较稳定。circRNA由于其表达的特异性和调控的复杂性,以及在疾病发生中的...
1、微小RNA(microRNA, miRNA) miRNA是短ncRNA,约为22～23个核苷酸,其编码基因由RNA多聚酶Ⅱ转录,通过与mRNA 3′端非翻译区(3′ untranslated region, 3′UTR)之间的结合调控mRNA的表达,超过60%的编码基因是miRNA的潜在调控靶点。 2、长链非编码RNA(long non-coding RNA, lncRNA) ...