1.和siRNA一样装载成RISC(RNA induced silencing complex , RISC;沉默复合物)后互补配对的mRNA降解; 2.miRNA可抑制mRNA的翻译,降低靶基因的蛋白质水平但不影响期mRNA的水平。 三、lncRNA(long non-coding RNA) IncRNA的长度一般大于200bp。根据基因组位点或相关的DNA特征,可以进一步进行分类(图4): 图4 长链非...
ncRNA为蛋白质编码的RNA分子,而是在细胞内执行其他功能。ncRNA基因有许多类型,其中一些包括: 转移RNA(tRNA):tRNA负责在蛋白质合成过程中将氨基酸带到核糖体上。有20种不同的tRNA基因,每种基因都编码一种特…
ciRNAs的形成依赖于侧翼RNA元件。侧翼RNA元件可能对内含子脱支成套非常重要。研究发现一些ciRNAs定位在细胞核中,可以与PolⅡ结合通过cis 作用模式调控宿主的转录活性。研究发现一类叫做EIciRNA的环状RNA与RNA PolⅡ关系密切。比如circEIF3J 和circPAIP2,定位在细胞核,与U1小核核糖核蛋白(snRNPs)结合,通过cis-ac...
Non-codingRNA:Versatilityinformandfunction NoncodingRNAgenesaresurprisinglynumerous.NoncodingRNAhaveaverydifferentfunctions.TimeforRNomics Cell,89:669–672,May30,1997 PNAS,97(26):14035-14037,Dec19,2000 UnderstandingRNomicsfromanexpendingsnoRNAworld CouzinJ.Breakthroughoftheyear.SmallRNAsmakebigsplash.Science...
1、微小RNA(microRNA, miRNA) miRNA是短ncRNA,约为22~23个核苷酸,其编码基因由RNA多聚酶Ⅱ转录,通过与mRNA 3′端非翻译区(3′ untranslated region, 3′UTR)之间的结合调控mRNA的表达,超过60%的编码基因是miRNA的潜在调控靶点。 2、长链非编码RNA(long non-coding RNA, lncRNA) ...
Noncoding RNAs, by definition, do not become translated into protein. This broad category includes cellular RNAs that range in size from 20 to 20,000 nucleotides, can contain chemical modifications, adopt a wide variety of secondary and tertiary structures, associate with proteins and other RNA ...
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non-coding rna名词解释non-coding rna名词解释 非编码RNA(non-coding RNA,ncRNA)指的是在转录成RNA时不被翻译成蛋白质的RNA分子。与编码蛋白质的mRNA相比,ncRNA的功能非常多样,包括调控基因表达、RNA的剪接和稳定性、染色体转录后修饰等。非编码RNA是生物学研究领域中的一个热门话题,对于揭示细胞及多细胞生命现象的...
Classical examples of non-coding RNAs include ribosomal RNAs and tRNAs, which represent 90% and 15% of the total RNA content of a typical mammalian cell, respectively. Additional types of non-coding RNAs, which have been shown to play both regulatory and signaling roles, were discovered in ...
Non-codingRNA(非编码RNA)非编码RNA是指不编码蛋白质的RNA。其中包括rRNA,tRNA,snRNA,snoRNA和microRNA等多种已知功能的RNA,还包括未知功能的RNA。这些RNA的共同特点是都能从基因组上转录而来,但是不翻译成蛋白,在RNA水平上就能行使各自的生物学功能了。第四页第,三共页102页。分类 非编码RNA从长度上来划分...