Although BC200 RNA was originally identified as a neuron-specific non-coding RNA, it is overexpressed in various cancer tissues. Recently, BC200 RNA was shown to promote metastasis in several cancer cell lines,
Emerging role of non‐coding RNA in health and disease Gurjit Kaur Bhatti Naina Khullar Jasvinder Singh Bhatti Metabolic Brain Disease(2021) The box C/D snoRNP assembly factor Bcd1 interacts with the histone chaperone Rtt106 and controls its transcription dependent activity ...
Long non-coding RNAs (lncRNAs) can often function in the regulation of gene expression during development; however, their generality as essential regulators in developmental processes and organismal phenotypes remains unclear. Here, we performed a tailored investigation of lncRNA expression and function ...
Regulatory RNA is emerging as the major architect of cognitive evolution and innovation in the mammalian brain. While the protein machinery has remained largely constant throughout animal evolution, the non protein-coding transcriptome has expanded consi
(ncRNAs), particularly microRNAs, long non-coding RNAs, and circular RNAs, have been shown to be crucial regulators in the initiation and development of CVDs. They can participate in CVD progression by impacting mitochondria and regulating mitochondrial function-related genes and signaling pathways. ...
Thus, the ARS and the poly(A) tail are not interchangeable for osk noncoding RNA function, suggesting that the role of the ARS is not in recruitment of Poly(A) binding protein (PABP), the protein that binds the poly(A) tail. Furthermore, although PABP has been implicated in transport...
Increasing evidence has revealed that long non-coding RNAs (lncRNAs) play a pivotal role in the development of nervous system. Our previous studies have demonstrated that enhanced cholinergic neurogenesis occurs in the subgranular zone (SGZ) of the hippo
that it has no obvious function in regulating its neighbor Cdkn1b," he said. He emphasized, however, that in determining the function of non-coding DNA and RNA, both DNA-deletion and RNA-blocking experiments—as in this study—are needed to distinguish the function of DNA from its RNA ...
Small non-coding RNAs (sncRNAs) are series of RNA species of <300 nucleotides (nt) in length [1], which are associated with malignancy through mediating gene expression and cancer signaling pathways [2, 3]. As the superstar of sncRNAs, the microRNA (miRNA), which is 19–25 nt in ...
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