Additional noncoding RNA (ncRNA)-based therapeutic approaches — targeting microRNAs and long ncRNAs — are now also gaining interest. Here, Calin and co-authors assess the hurdles facing the clinical translation of ncRNA-based therapeutics and highlight promising emerging solutions to address these issues.doi:10.1038/s41573-021...
alternative splicing, RNA editing, and alternative polyadenylation. These different types of RNA variations have also been demonstrated to be connected with tumorigenesis. tRNA, transfer RNA; rRNA, ribosomal RNA; lncRNA, long noncoding RNA; circRNA, circular RNA; siRNA, small...
Non-coding RNA Research aims to publish high quality research and review articles on the mechanistic role of non-coding RNAs in all human diseases. This interdisciplinary journal will welcome research dealing with all aspects of non-coding RNAs-their biogenesis, regulation and role in disease … Vi...
antisense transcripts (NATs), non-coding RNA expansion repeats, promoter-associated RNAs (PARs),enhancer RNAs(eRNAs), small activating RNAs (saRNAs, RNAa)[12,25,26].Small ncRNAs(miRNAs, siRNAs, piRNAs) show mature forms of 20–30 nucleotides (nt) that associate with members of theArgonaute(...
NoncodingRNAgenesaresurprisinglynumerous.NoncodingRNAhaveaverydifferentfunctions.TimeforRNomics Cell,89:669–672,May30,1997 PNAS,97(26):14035-14037,Dec19,2000 UnderstandingRNomicsfromanexpendingsnoRNAworld CouzinJ.Breakthroughoftheyear.SmallRNAsmakebigsplash.Science.2002Dec20;298(5602):2296-7.DNA RNA...
Non-coding RNA Research(《非编码RNA研究》(英文),简称NCRNA)创刊于2016年12月,是由中国科学院主管,科学出版社主办,科爱公司运营的高质量国际开放获取期刊,旨在发表高水平的研究论文和综述,传播前沿研…
Repertor:Xiaoning Yuan Oct.9.2012 Irnne.MP,Cheng G,Wieland.S,et al,2007 Noncoding RNA ? Introduction ? Classification ? Research method ? Mechanism ? The relationship with major disease 1.Introduction Noncoding RNA(ncRNA) is a kind of transcripts without the ability of coding proteins,which ...
Noncoding RNAnoncoding RNA and ENCODE Pilot Projectconserved ncRNAs with limited distributionncRNAs from repeats and pseudogenesdoi:10.1002/9780470570418.ch14Alexander DonathSven FindeiβJana HertelManja MarzWolfgang OttoChristine SchulzPeter F. Stadler...
6月18日,Nature Review Drug Discovery发表了一篇题为“Noncoding RNA therapeutics — challenges and potential solutions”的文章,对非编码RNA(ncRNA)疗法可能面临的挑战和解决方案进行了总结。 过去的十年里,基于RNA的疗法在临床应用方面发挥了巨大作用,主要采用(ASO)反义寡核苷酸和小干扰核糖核酸(siRNA)这两种技术。
circRNA是一类以共价封闭环为特征,广泛存在于真核生物中的新型RNA分子。CircRNA来源于基因的外显子或者内含子区域,在哺乳动物细胞中大量存在。现有研究表明大部分的circRNA在不同物种间是保守的。同时,由于其环状结构能抵抗RNase R的降解而比较稳定。circRNA由于其表达的特异性和调控的复杂性,以及在疾病发生中的...