The advent of high-throughput sequencing uncovered that our genome is pervasively transcribed into RNAs that are seemingly not translated into proteins. It was also found that non-coding RNA transcripts outnumbe
Non-coding RNAs (ncRNAs) are ribonucleic acid (RNA) molecules that are not translated into protein products. Different classes of non-coding RNAs participate in different cellular processes; for example, gene expression regulation (miRNAs, piRNAs, lncRNAs), RNA maturation (snRNAs, snoRNAs) and prot...
图1 基因组中总RNA与非编码RNA 人类基因组中有四分之三的基因可以进行转录,但是能翻译成蛋白质发挥功能的基因只占一小部分,基因组中绝大多数的基因是非编码RNA(ncRNA)。ncRNA是一类不编码蛋白质的RNA,但其对编码基因的表达以及相应功能的调控起这重要的作用。ncRNA根据RNA的大小可分为3大类(图1)。 图2 ncRNA...
non-coding RNA非编码RNA:是指各种不翻译成蛋白质的RNA分子。包括rRNA,tRNA,snRNA,siRNA 和miRNA 等多种 RNA。这些RNA的共
ncRNA为蛋白质编码的RNA分子,而是在细胞内执行其他功能。ncRNA基因有许多类型,其中一些包括: 转移RNA(tRNA):tRNA负责在蛋白质合成过程中将氨基酸带到核糖体上。有20种不同的tRNA基因,每种基因都编码一种特…
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non-coding rna名词解释non-coding rna名词解释 非编码RNA(non-coding RNA,ncRNA)指的是在转录成RNA时不被翻译成蛋白质的RNA分子。与编码蛋白质的mRNA相比,ncRNA的功能非常多样,包括调控基因表达、RNA的剪接和稳定性、染色体转录后修饰等。非编码RNA是生物学研究领域中的一个热门话题,对于揭示细胞及多细胞生命现象的...
Non-codingRNAsare those RNAs that do not undergo the translation process ofprotein synthesis. Non-codingRNA(ncRNA) molecules are transcribed from more than 70% of the genome. More than 40 different types ofnon-coding RNAsare known and they are mostlyribosomal RNAs(rRNAs), transfer RNAs (tRNAs...
1、微小RNA(microRNA, miRNA) miRNA是短ncRNA,约为22～23个核苷酸,其编码基因由RNA多聚酶Ⅱ转录,通过与mRNA 3′端非翻译区(3′ untranslated region, 3′UTR)之间的结合调控mRNA的表达,超过60%的编码基因是miRNA的潜在调控靶点。 2、长链非编码RNA(long non-coding RNA, lncRNA) ...
Non-codingRNA:Versatilityinformandfunction NoncodingRNAgenesaresurprisinglynumerous.NoncodingRNAhaveaverydifferentfunctions.TimeforRNomics Cell,89:669–672,May30,1997 PNAS,97(26):14035-14037,Dec19,2000 UnderstandingRNomicsfromanexpendingsnoRNAworld CouzinJ.Breakthroughoftheyear.SmallRNAsmakebigsplash.Science...