Long noncoding RNAs (lncRNAs), which lacking protein-coding ability, have recently emerged as pivotal participants in biological processes, often dysregulated in a range of cancers, including lung cancer. In thi
et al. Polycomb associates genome-wide with a specific RNA polymerase II variant, and regulates metabolic genes in ESCs. Cell Stem Cell 10, 157–170 (2012). CAS PubMed PubMed Central Google Scholar Devaiah, B. N. et al. BRD4 is an atypical kinase that phosphorylates serine2 of the ...
RNAseq is a comprehensive sequencing technique used to study gene expression and transcription regulation within cells.Extraction of RNA: The process begins with the extraction of total RNA, which includes both mRNA and noncoding RNA, from cells or tissue samples.Preparation of RNA Li...
Long noncoding RNA-HOTAIR affects chemoresistance by regulating HOXA1 methylation in small cell lung cancer cells. Lab. Invest. 96, 60–68 (2016). CAS PubMed Google Scholar Pettengill, O. S., Carney, D. N., Sorenson, G. D. & Gazdar, A. F. in The Endocrine Lung in Health and ...
Small RNA-seq is a type of RNA-seq that isolates small noncoding RNAs (e.g., microRNAs). This approach allows researchers to investigate the role of small RNAs in post-transcriptional gene expression regulation, heterochromatin formation, and other cellular functions. In a small RNA-seq workflow...
The long noncoding RNA MIR503HG directly binds to H2A.Z, as identified through RNA pull-down assays followed by mass spectrometry and validated by immunoblots (64). MIR503HG is thought to negatively influence gene expression, as its overexpression affects H2A.Z recruitment to chromatin and ...
MSC mesenchymal stem cell ncRNA noncoding RNA TC therapeutic candidate All eukaryotic cells secrete, and take up, exosomes. These tiny extracellular vesicles (EVs) are laden with genetic instructions that influence recipient cells, sometimes subtly, sometimes dramatically. Over the last 2 decades, scie...
It also found that these noncoding RNA are transcribed by a class of satellite DNA, although they do not produce proteins, their regulatory role is closely related to the growth of tumor [25, 26]. Mutational characteristics in various cancers An analysis based on TCGA data shows that there ...
Antisense non-coding RNA in the INK4 locus ARDS: Acute respiratory distress syndrome ATG: Autophagy-related-genes BBB: Blood–brain barrier C5aR: C5a receptor CD: Cluster of differentiation CJD: Cruetzfeldt-Jacob disease CNS: Central nervous system ...
Thepromoter, a DNA sequence that liesupstreamof the RNA coding region, serves as an indicator of where and in which direction transcription should proceed. The promoter is not actually transcribed; its role is purely regulatory. While promoters vary tremendously among eukaryotes, there are some comm...