Long noncoding RNAs (lncRNAs), which lacking protein-coding ability, have recently emerged as pivotal participants in biological processes, often dysregulated in a range of cancers, including lung cancer. In thi
RNAseq is a comprehensive sequencing technique used to study gene expression and transcription regulation within cells.Extraction of RNA: The process begins with the extraction of total RNA, which includes both mRNA and noncoding RNA, from cells or tissue samples.Preparation of RNA Li...
Small RNA-seq is a type of RNA-seq that isolates small noncoding RNAs (e.g., microRNAs). This approach allows researchers to investigate the role of small RNAs in post-transcriptional gene expression regulation, heterochromatin formation, and other cellular functions. In a small RNA-seq workflow...
Pancreatic cancer (PC) is one of the leading causes of cancer-related deaths worldwide. Due to the shortage of effective biomarkers for predicting survival and diagnosing PC, the underlying mechanism is still intensively investigated but poorly understood. Long noncoding RNAs (lncRNAs) provide biologi...
et al. Polycomb associates genome-wide with a specific RNA polymerase II variant, and regulates metabolic genes in ESCs. Cell Stem Cell 10, 157–170 (2012). CAS PubMed PubMed Central Google Scholar Devaiah, B. N. et al. BRD4 is an atypical kinase that phosphorylates serine2 of the ...
RNA sequencing is the process of determining the sequence of nucleotides in a strand of ribonucleic acid. While RNA sequencing...
Long noncoding RNA-HOTAIR affects chemoresistance by regulating HOXA1 methylation in small cell lung cancer cells. Lab. Invest. 96, 60–68 (2016). CAS PubMed Google Scholar Pettengill, O. S., Carney, D. N., Sorenson, G. D. & Gazdar, A. F. in The Endocrine Lung in Health and ...
It also found that these noncoding RNA are transcribed by a class of satellite DNA, although they do not produce proteins, their regulatory role is closely related to the growth of tumor [25, 26]. Mutational characteristics in various cancers An analysis based on TCGA data shows that there ...
What is non-genetic RNA? What is RNA and DNA (in biology)? What is an antisense strand in DNA replication? DNA which is loosely wrapped around protein is referred to as: a. RNA b. chromosome c. chromatid d. chromatin What is responsible for replacing RNA with DNA in DNA replication?
Whole-transcriptome sequencing provides sequence information about coding and multiple noncoding forms of RNA to assess variations and gene expression levels across the entire transcriptome. Targeted sequencing covers a relatively small set of genes or targeted regions of interes...