Nod-Like Receptor Protein 3 Inflammasome-Dependent Il-1β Accelerated Cona-Induced Hepatitis Autoimmune hepatitis (AIH) is a progressive inflammatory disorders of unknown etiology, characterized by immune-mediated destruction of hepatocytes and massive production of cytokines. Interleukin-1β is a pleiotropi...
Nod-like receptor protein 3 (NLRP3) inflammasome has been implicated in alcoholic liver disease. Chronic alcohol consumption enhances gut permeability and causes microbial translocation. The present study explored the activation of the NLRP3 inflammasome by Escherichia coli RNA in hepatic stellate cells ...
Of the multiple inflammasomes, the NOD-like receptor protein 3 (NLRP3) inflammasome is activated by endogenous molecules that are released as a result of tissue injury and thus is ideally positioned to produce the majority of postoperative IL-1β. Therefore, we aimed to uncover the mechanism by...
NOD样受体（Nod-like receptor, NLR）家族是机体最大的一类模式识别受体；目前认为NLR感知识别相应模式分子后，可通过自身寡聚化组装形成大型信号分子机器, 如NLRP3，NLRC4等形成的炎症小体（Inflammasome），NOD2等形成的Nodosome，从而激活NF-κB通路、MAPK通路、细胞焦亡等，释放TNFα，IL-1β和IL-18等炎性细胞...
Accompanied by activation of the NOD-like receptor protein 3 (NLRP3) inflammasome, aberrant connexin 43 (Cx43) hemichannel-mediated ATP release is situated upstream of inflammasome assembly and inflammation and contributes to multiple secondary complicat
Role of the thioredoxin interacting protein in diabetic nephropathy and the mechanism of regulating NOD‑like receptor protein 3 inflammatory corpuscle. Int J Mol Med. 2019;43:2440–50. CAS PubMed PubMed Central Google Scholar Wang S, Zhao X, Yang S, Chen B, Shi J. Salidroside alleviates...
Excessive NLRP3 inflammasome activation underlies inflammatory diseases such as gout. Here the authors show that orphan nuclear receptor small heterodimer partner protein (SHP) negatively regulates NLRP3, and its loss leads to accumulation of damaged mitochondria and gout-like immunopathology. Chul-Su Yan...
Dietary saturated fatty acid and polyunsaturated fatty acid oppositely affect hepatic NOD-like receptor protein 3 inflammasome through regulating nuclear factor-kappa B activation[J]. Yong-heng Sui,Wen-jing Luo,Qin-Yu Xu,jing hua.World Journal of Gastroenterology. 2016(08)Sui YH, Luo WJ, Xu Q ...
Among the various types of inflammasomes, the nod-like receptor protein 3 (NLRP3) inflammasome has been extensively studied in adipose tissue. The Nlrp3, Casp1 and Il1b knockout mice were protected from high-fat diet-induced adipose insulin resistance [15, 16, 17, 18], but it is unclear...
speck-like protein containing a CARD (ARC) and the cysteine protease caspase-1, leading to maturation and secretion of the proinflammatory cytokine IL-1b. 8-10 NOD-like receptor family, pyrin domain containing 3 (NLRP3) is one of the most important intracellular pattern recognition receptor...