Nod-like receptor protein 3 (NLRP3) inflammasome activation and podocyte injury via thioredoxin-interacting protein (TXNIP) during hyperhomocysteinemia. The Journal of biological chemistry. 2014; 289(39):27159-27168.Abais, J.M., Xia, M., Li, G., Chen, Y., Conley, S.M., Gehr, T.W....
intervention with recombinant human interleukin-1 receptor antagonist (rhIL-1Ra) strongly suppressed ConA-induced hepatitis by decreasing tumor necrosis factor-alpha (TNF-α) and interleukin-17 (IL-17) secretion, and inflammatory cell infiltration into livers. Additionally, rhIL-1Ra-pretreated mice develo...
NOD样受体（Nod-like receptor, NLR）家族是机体最大的一类模式识别受体；目前认为NLR感知识别相应模式分子后，可通过自身寡聚化组装形成大型信号分子机器, 如NLRP3，NLRC4等形成的炎症小体（Inflammasome），NOD2等形成的Nodosome，从而激活NF-κB通路、MAPK通路、细胞焦亡等，释放TNFα，IL-1β和IL-18等炎性细胞...
Of the multiple inflammasomes, the NOD-like receptor protein 3 (NLRP3) inflammasome is activated by endogenous molecules that are released as a result of tissue injury and thus is ideally positioned to produce the majority of postoperative IL-1β. Therefore, we aimed to uncover the mechanism by...
MCE 站:NOD-like Receptor 品牌:MedChemExpress (MCE) 概述:核苷酸寡聚结构域 (NOD) 样受体 (NLR) 是关键的细胞质模式识别受体 (PRR),在宿主先天免疫反应和免疫稳态中发挥重要作用。人类中有 23 个 NLR 家族成员,小鼠中有至少 34 个 NLR 基因。 NLR 在许多细胞类型中表达,包括免疫细胞和上皮细胞,尽管某些...
3) Toll-like receptor Toll样受体 1. Advancement of the relationship between gene polymorphisms of Toll-like receptors and infectious diseases; Toll样受体及其基因多态性与感染性疾病关系的研究进展 2. Change of toll-like receptor mRNA expression in peritoneal macrophages of immunosuppressed mice; ...
NOD-like Receptor (NLR) ¥ 148 现货 规格 数量 MCC950 sodium CRID3 sodium salt, CP-456773, CP-456773 sodium, MCC950 T6887256373-96-3 MCC950 sodium (CP-456773 sodium) 是一种炎症小体 NLRP3 的抑制剂 (IC50=7.5 nM in BMDMs; IC50=8.1 nM in HMDMs),具有高效选择性。MCC950 sodium 对其他...
Aim: To investigate whether miR-22 is involved in the proliferation, invasion, and migration of melanoma cells (MCs) by negatively regulating NOD-like receptor protein 3 (NLRP3) gene. Material and methods: Human MCs (WM239a) and human epidermal melanocytes (HEM) were ...
Nucleotide-binding oligomerization domain-like receptor pyrin domain-containing-3 (NLRP3) plays a role in inflammatory diseases. The aims of this study were to determine the effect of term labor on the expression of NLRP3 in human myometrium and the effect of NLRP3 silencing on pro-labor ...
receptor protein, CASP1, sometimes also CASP5 and the adaptor protein PYCARD that is a key component of the inflammasomes. The inflammasome assembly is trigged by the interaction of PYCARD with the receptor molecule. Using its CARD domain, PYCARD brings pro-CASP1 into close proximity, which ...