NOD样受体（Nod-like receptor, NLR）家族是机体最大的一类模式识别受体；目前认为NLR感知识别相应模式分子后，可通过自身寡聚化组装形成大型信号分子机器, 如NLRP3，NLRC4等形成的炎症小体（Inflammasome），NOD2等形成的Nodosome，从而激活NF-κB通路、MAPK通路、细胞焦亡等，释放TNFα，IL-1β和IL-18等炎性细胞...
Nod-like receptor protein 1 inflammasome mediates neuron injury under high glucose. Mol Neurobiol. 2014;49:673–84.Nod-Like Receptor Protein 1 Inflammasome Mediates Neuron Injury under High Glucose[J] . Xian-Fang Meng,Xiao-Lan Wang,Xiu-Juan Tian,Zhi-Hua Yang,Guang-Pin Chu,Jing Zhang,Man Li...
intervention with recombinant human interleukin-1 receptor antagonist (rhIL-1Ra) strongly suppressed ConA-induced hepatitis by decreasing tumor necrosis factor-alpha (TNF-α) and interleukin-17 (IL-17) secretion, and inflammatory cell infiltration into livers. Additionally, rhIL-1Ra-pretreated mice develo...
NLR family NLR, a nucleotide-binding oligomeric domain receptor, is a class of PRR that is widely present in the cytoplasm of innate immune cells. It consists of three domains, including a C-terminal Leucine-rich repeat domain (LRR) that mediates a ligand protein, a central nucleic acid bind...
© 2012 IBCB, SIBS, CAS All rights reserved 1001-0602/12 $ 32.00 www.nature.com/cr npg NLRC5: a NOD-like receptor protein with many faces in immune regulation Yue Zhao1, Feng Shao1 1National Institute of Biological Sciences, 7# Science Park Rd, Zhongguancun Life Science Park, Beijing...
Of the multiple inflammasomes, the NOD-like receptor protein 3 (NLRP3) inflammasome is activated by endogenous molecules that are released as a result of tissue injury and thus is ideally positioned to produce the majority of postoperative IL-1β. Therefore, we aimed to uncover the mechanism by...
The innate immune receptor NOD2 is tightly regulated to ensure beneficial antimicrobial immunity. Here the authors show that the H2A deubiquitinase MYSM1 restrains NOD2 signaling by removing lysine 63 (K63), K27, M1 but not K48 polyubiquitin chains from its downstream adaptor protein RIP2. Swar...
( N l R ) ApprovedNameOtherNamesandAliasesNLRFamilyDomainOrganization CIITAclassII,majorhistocompatibilitycomplex,transactivatorNLRA;MHC2TA;C2TANLRA(CARD)-AD-NACHT-NAD-LRR NAIPNLRfamily,apoptosisinhibitoryproteinNLRB1;BIRC1;CLR5.1NLRBBIR3x-NACHT-LRR NOD1nucleotide-bindingoligomerizationdomaincontaining1NLRC1...
Fig. 1: Protein structures of each NLR subfamily. Human NLRs are divided into five subfamilies: NLRA, NLRB, NLRC, NLRP, and NLRX. All NLRs except NLRP10 contain an N-terminal effector domain, a central NACHT domain and a C-terminal LRR domain. CARD caspase recruitment domain, AD acidic ...
系统标签: nlrsnodreceptorsnlrpnlrpyrin .adipogen InternationalEdition FIGURE1:OverviewonPAMPsandDAMPsrecognizedbyNLRs. NOD-likeReceptors(NLRs) andInflammasomes Inmammals,germ-lineencodedpatternrecognitionreceptors(PRRs)detectthepresence ofpathogensthroughrecognitionofpathogen-associatedmolecularpatterns(PAMPs)or endogeno...