intervention with recombinant human interleukin-1 receptor antagonist (rhIL-1Ra) strongly suppressed ConA-induced hepatitis by decreasing tumor necrosis factor-alpha (TNF-α) and interleukin-17 (IL-17) secretion, and inflammatory cell infiltration into livers. Additionally, rhIL-1Ra-pretreated mice develo...
resulting in a series of inflammatory responses that ultimately lead to the occurrence of various diseases. The Nod-like receptor protein 3 (NLRP3) inflammasome is the most
Accompanied by activation of the NOD-like receptor protein 3 (NLRP3) inflammasome, aberrant connexin 43 (Cx43) hemichannel-mediated ATP release is situated upstream of inflammasome assembly and inflammation and contributes to multiple secondary complications of diabetes and associated cardiometabolic comorbi...
Recently,the roles of pyroptosis,a form of cell death induced by activated NODlike receptor protein 3(NLRP3)inflammasome,in the pathogenesis of diabetic cardiomyopathy(DCM)have been extensively investigated.However,most studies have focused mainly on whether diabetes increases the NLRP3 inflammasome and...
研究[10]表明,TLR4/NF-κB信号通路调控多种炎症介质和细胞因子的表达,从而激活NOD样受体蛋白3(NOD-like receptor protein3,NLRP3)途径释放一系列炎症介质再度激活TLR4/NF-κB信号通路来放大炎症级联反应。因此,本研究采用逆行胰胆管注射牛磺胆酸钠构建了SAP小鼠模型,以探索清解化攻方调控NLRP3/TLR4/NF-κB信号通路...
The adipose Nod-like receptor protein 3 (NLRP3) inflammasome senses danger-associated molecular patterns (DAMPs) and initiates insulin resistance, but the mechanisms of adipose inflammasome activation remains elusive. In this study, Homocysteine (Hcy) is revealed to be a DAMP that activates adipocyte...
NLRC5 expression can be induced by toll-like receptor (TLR) ligands like LPS and poly(I:C), interferons, or viral infec- tion, but the most prominent effect is observed with IFN-γ [1, 7-10]. IFN-γ is a potent stimulator of MHC class I expression, which requires NLRC5 expression ...
The adipose Nod-like receptor protein 3 (NLRP3) inflammasome senses danger-associated molecular patterns (DAMPs) and initiates insulin resistance, but the mechanisms of adipose inflammasome activation remains elusive. In this study, Homocysteine (Hcy) is revealed to be a DAMP that activates adipocyte...
Discovery and optimization of 4-oxo-2-thioxo-thiazolidinones as NOD-like receptor (NLR) family, pyrin domain-containing protein 3 (NLRP3) inhibitors Author links open overlay panelYun Chen a 1, Hongbin He b 1, Hua Jiang b 1, Li Li a, Zhiyu Hu a, Huiying Huang a, Qingyan Xu a, ...
Pattern recognition receptors of the immune system have key roles in the regulation of pathways after the recognition of microbial- and danger-associated molecular patterns in vertebrates. Members of NOD-like receptor (NLR) family typically function intr