NOD样受体（Nod-like receptor, NLR）家族是机体最大的一类模式识别受体；目前认为NLR感知识别相应模式分子后，可通过自身寡聚化组装形成大型信号分子机器, 如NLRP3，NLRC4等形成的炎症小体（Inflammasome），NOD2等形成的Nodosome，从而激活NF-κB通路、MAPK通路、细胞焦亡等，释放TNFα，IL-1β和IL-18等炎性细胞...
Xia, G. Li et al., "Nod-like receptor protein 3 (NLRP3) inflammasome activation and podocyte injury via thioredoxin-interacting protein (TXNIP) during hyperhomo- cysteinemia," The Journal of Biological Chemistry, vol. 289, no. 39, pp. 27159-27168, 2014....
intervention with recombinant human interleukin-1 receptor antagonist (rhIL-1Ra) strongly suppressed ConA-induced hepatitis by decreasing tumor necrosis factor-alpha (TNF-α) and interleukin-17 (IL-17) secretion, and inflammatory cell infiltration into livers. Additionally, rhIL-1Ra-pretreated mice develo...
NOD样受体热蛋白结构域相关蛋白3(NOD-like receptor domain-containing protein 3,简称NLRP3)是一种重要的炎症调控蛋白,在免疫应答和疾病发生发展过程中扮演着关键角色。本文将从NLRP3的结构特点、功能调控以及与疾病的关联性等方面进行阐述。 NLRP3是一种由1054个氨基酸组成的蛋白质,具有多个结构域,包括一个N端的信...
Here the authors show that orphan nuclear receptor small heterodimer partner protein (SHP) negatively regulates NLRP3, and its loss leads to accumulation of damaged mitochondria and gout-like immunopathology. Chul-Su Yang , Jwa-Jin Kim & Eun-Kyeong Jo Article | 20 August 2014 Aryl hydrocarbon...
Of the multiple inflammasomes, the NOD-like receptor protein 3 (NLRP3) inflammasome is activated by endogenous molecules that are released as a result of tissue injury and thus is ideally positioned to produce the majority of postoperative IL-1β. Therefore, we aimed to uncover the mechanism by...
【关键词】NLRP3炎性小体; 钙离子信号; 活化机制Nod样受体蛋白(Nod-like receptor protein 3,NLRP3)炎性小体作为重要的固有免疫组成部分,能对包括入侵病原体、宿主细胞衍生的危险信号和环境刺激物在内的各种刺激做出反应,在机体免疫反...
NOD样受体热蛋白结构域相关蛋白3(NOD-like receptor family pyrin domain containing protein 3,NLRP3)是一种重要的多功能蛋白质,参与多种疾病的发生和发展。NLRP3被广泛表达于多种细胞类型,包括单核细胞、巨噬细胞、肺上皮细胞、血管内皮细胞等,其结构包含Pyrin结构域、NOD结构域和LRR结构域。 NLRP3常被称为是炎...
Nod样受体(NLRs)是多种先天免疫反应的模式识别受体。与配体结合后的自寡聚化是每个NLR活化的普遍接受的模型。2023年3月21日，厦门大学韩家淮团队在Immunity（IF=43）在线发表题为“Ribosome-rescuer PELO catalyzes the oligomeric assembly of NOD-like receptor family proteins via activating their ATPase enzymatic ...
Role of the thioredoxin interacting protein in diabetic nephropathy and the mechanism of regulating NOD‑like receptor protein 3 inflammatory corpuscle. Int J Mol Med. 2019;43:2440–50. CAS PubMed PubMed Central Google Scholar Wang S, Zhao X, Yang S, Chen B, Shi J. Salidroside alleviates...