NLRP3为NOD样受体热蛋白结构域相关蛋白3(NOD-like receptor thermal protein domain associated protein 3, NLRP3),是NOD样受体家族中重要的一员,其炎性小体复合物由NLRP3、凋亡相关斑点样蛋白(apoptosis-associated speck-like protein containing a CARD, ASC)和半胱天冬酶-1前体(pro-cysteinyl aspartate specific...
NOD样受体热蛋白结构域相关蛋白3(NOD-like receptor domain-containing protein 3,简称NLRP3)是一种重要的炎症调控蛋白,在免疫应答和疾病发生发展过程中扮演着关键角色。本文将从NLRP3的结构特点、功能调控以及与疾病的关联性等方面进行阐述。 NLRP3是一种由1054个氨基酸组成的蛋白质,具有多个结构域,包括一个N端的信...
NOD样受体热蛋白结构域相关蛋白3(NOD-like receptor family pyrin domain containing protein 3,NLRP3)是一种重要的多功能蛋白质,参与多种疾病的发生和发展。NLRP3被广泛表达于多种细胞类型,包括单核细胞、巨噬细胞、肺上皮细胞、血管内皮细胞等,其结构包含Pyrin结构域、NOD结构域和LRR结构域。 NLRP3常被称为是炎...
NOD样受体热蛋白结构域相关蛋白3(NOD like receptor thermal protein domain associated protein 3, NLRP3)炎症小体是细胞内的一类多蛋白复合物,已经被证实在ALI的发病过程中扮演重要角色。激活炎症小体的因素多种多样,而线粒体在其中发挥的作用正受到越来越多的关注,除了线粒体激活NLRP3炎症小体的独特机制,临床上...
In recent years, NOD-like receptor protein 3 (NLRP3) inflammasome in tumors has become a research hotspot, especially in melanoma, colorectal cancer, lung cancer, and breast cancer, and more and more evidence has shown that inflammation plays a role in the development, progression, ...
we first investigated the significance of NOD-like receptor protein 3 (NLRP3) inflammasome-dependent IL-1β in the pathogenesis of AIH with a murine model of immune-mediated hepatitis induced by Concanavalin A (ConA). In ConA-treated mice, pathogenic elevated NLRP3, Cleaved caspase-1 and IL-...
Of the multiple inflammasomes, the NOD-like receptor protein 3 (NLRP3) inflammasome is activated by endogenous molecules that are released as a result of tissue injury and thus is ideally positioned to produce the majority of postoperative IL-1β. Therefore, we aimed to uncover the mechanism by...
类风湿性关节炎等自身免疫性疾病中,NET中的蛋白质-DNA复合物通过刺激巨噬细胞中的NOD样受体热蛋白结构域相关蛋白3(NOD-like receptor thermal protein domain associated protein 3,NLRP3)炎症小体,切割白细胞介素(interleukin,IL)-1...
品牌:睿创英文名称:HumanNODlikereceptorfamilyprotein3(NLPR3)ELISAkit货号:RC-R201529E人NOD样受体家族蛋白3(NLPR3)ELISA试剂盒规格:96T/48T 用途:科研实验专用,不得用于临床诊断,请按说明书严格操作样本:血清,血浆,唾液,尿液,组织,细胞上清,裂解液等适应物种:人,小鼠,大鼠,植物,鱼,虾,蟹,牛,羊,狗,猫,...
英文名称:Human NOD-like receptor family protein 3(NLPR3)ELISA kit 用途:科研试验 产地:上海 品牌:佰利莱生物 包装规格:96T/48T 标记物:HRP标记物 样本:血清,血浆,唾液,尿液,组织,细胞上清,裂解液等 检测方法:酶联免疫法 应用:定性检测/定量检测/酶活检测 ...