Nod-like receptor protein 3 (NLRP3) inflammasome is a multi-protein complex that controls the production of pro-inflammatory cytokines, IL-18 and IL-1尾, through caspase-1 activation. These inflammatory cytokines play an important role in the development of multiple sclerosis (MS). The ...
Of the multiple inflammasomes, the NOD-like receptor protein 3 (NLRP3) inflammasome is activated by endogenous molecules that are released as a result of tissue injury and thus is ideally positioned to produce the majority of postoperative IL-1β. Therefore, we aimed to uncover the mechanism by...
we first investigated the significance of NOD-like receptor protein 3 (NLRP3) inflammasome-dependent IL-1β in the pathogenesis of AIH with a murine model of immune-mediated hepatitis induced by Concanavalin A (ConA). In ConA-treated mice, pathogenic elevated NLRP3, Cleaved caspase-1 and IL-...
Among the various types of inflammasomes, the nod-like receptor protein 3 (NLRP3) inflammasome has been extensively studied in adipose tissue. The Nlrp3, Casp1 and Il1b knockout mice were protected from high-fat diet-induced adipose insulin resistance [15, 16, 17, 18], but it is unclear...
NOD样受体（Nod-like receptor, NLR）家族是机体最大的一类模式识别受体；目前认为NLR感知识别相应模式分子后，可通过自身寡聚化组装形成大型信号分子机器, 如NLRP3，NLRC4等形成的炎症小体（Inflammasome），NOD2等形成的Nodosome，从而激活NF-κB通路、MAPK通路、细胞焦亡等，释放TNFα，IL-1β和IL-18等炎性细胞...
and Toll-like receptors and C-type lectin receptors are located in the plasma membrane and endosome [6]. At present, many inflammasomes are known, but the most powerful and the most extensively studied inflammasome is the Nod-like receptor protein 3 (NLRP3) inflammasome; therefore, we chose ...
speck-like protein containing a CARD (ARC) and the cysteine protease caspase-1, leading to maturation and secretion of the proinflammatory cytokine IL-1b. 8-10 NOD-like receptor family, pyrin domain containing 3 (NLRP3) is one of the most important intracellular pattern recognition receptor...
All NLR proteins contain a C-terminal leucine-rich repeat (LRR), except NLRP10, a centrally located nucleotide-binding domain known as the NACHT domain (named for neuronal apoptosis inhibitor protein (NAIP), major histocompatibility complex (MHC) class II transcription activator (CIITA), ...
The adipose Nod-like receptor protein 3 (NLRP3) inflammasome senses danger-associated molecular patterns (DAMPs) and initiates insulin resistance, but the mechanisms of adipose inflammasome activation remains elusive. In this study, Homocysteine (Hcy) is revealed to be a DAMP that activates adipocyte...
NLRP1/NALP1NLRP2/NALP2NLRP3/NALP3NLRP6/NALP6NLRP10/Pynod/NALP10NOD1 Table 2. Antibodies for Detecting Intracellular Molecules Involved in NOD-like Receptor Signaling - Products by Molecule ASCCARD9Caspase-1cIAP-1/HIAP-2cIAP-2/HIAP-1ERK1 ...