Nod-Like Receptor Protein 3 Inflammasome-Dependent Il-1β Accelerated Cona-Induced Hepatitis Autoimmune hepatitis (AIH) is a progressive inflammatory disorders of unknown etiology, characterized by immune-mediated destruction of hepatocytes and massive production of cytokines. Interleukin-1β is a pleiotropi...
Nod-like receptor protein 3 inflammasome activation by Escherichia coli RNA induces transforming growth factor beta 1 secretion in hepatic stellate cells. Wang H,Liu S,Wang Y,et al. Bosn J Basic Med Sci . 2016Wang H, Liu S, Wang Y, Chang B, Wang B. Nod-like receptor protein 3 ...
Of the multiple inflammasomes, the NOD-like receptor protein 3 (NLRP3) inflammasome is activated by endogenous molecules that are released as a result of tissue injury and thus is ideally positioned to produce the majority of postoperative IL-1β. Therefore, we aimed to uncover the mechanism by...
NOD样受体（Nod-like receptor, NLR）家族是机体最大的一类模式识别受体；目前认为NLR感知识别相应模式分子后，可通过自身寡聚化组装形成大型信号分子机器, 如NLRP3，NLRC4等形成的炎症小体（Inflammasome），NOD2等形成的Nodosome，从而激活NF-κB通路、MAPK通路、细胞焦亡等，释放TNFα，IL-1β和IL-18等炎性细胞...
细胞焦亡过程涉及多种炎症小体信号通路的激活,其中对NOD样受体家族Pyrin域蛋白(NOD-like receptors family Pyrin domain containing,NLRP)3炎症小体的研究较深入。目前,研究结果证实,NLRP3炎症小体诱导的细胞焦亡在骨髓增生异常综合征(myelodysplastic syndromes,MDS)发病中发挥重要作用 [ 1 ]。但是细胞焦亡是否参与除MDS...
The NLRP10 protein is found to form an inflammasome complex in response to mitochondrial damage. Loss of NLRP10 from colonic epithelia promotes inflammatory bowel disease in a mouse model, while a variant predisposing to atopic dermatitis also shows loss of function. ...
The NLRP3 inflammasome has been one of the most widely studied inflammasomes in recent years. In response to PAMPs/DAMPs, dimerized NLRP3 molecules polymerize the two PYD effector domains and activate apoptosis-associated speck-like protein containing a CARD (ASC) through a homophilic CARD–CARD in...
结论内质网应激和NLRP3参与重症中暑肠黏膜损伤,4-BPA通过抑制内质网应激及NLRP3炎症小体活化减轻重症中暑肠黏膜损伤。 关键词: 重症中暑;肠黏膜损伤;内质网应激;NOD样受体蛋白3;4-苯基丁酸 ABSTRACT ObjectiveTo observe whether endoplasmic reticulum stress and NOD-like receptor protein 3 (NLRP3) inflammasome activa...
Excessive NLRP3 inflammasome activation underlies inflammatory diseases such as gout. Here the authors show that orphan nuclear receptor small heterodimer partner protein (SHP) negatively regulates NLRP3, and its loss leads to accumulation of damaged mitochondria and gout-like immunopathology. Chul-Su Yan...
NOD样受体(Nod-like receptor, NLR)家族是机体最大的一类模式识别受体;目前认为NLR感知识别相应模式分子后,可通过自身寡聚化组装形成大型信号分子机器, 如NLRP3,NLRC4等形成的炎症小体(Inflammasome),NOD2等形成的Nodosome,从而激活NF-...