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NLRP1 and CARD8 have been described to form inflammasomes, molecular platforms essential for CARD-CARDmediated recruitment and activation of caspase-1 and cleavage of pro-IL-1脽[6,7].Hereditary polym...
Intriguingly, synthetic small molecule inhibitors of dipeptidyl peptidase 9 (DPP9), including Val-boroPro (VbP), potently activate the related NLRP1 and CARD8 inflammasomes (Figs. 1A and S1A) (3, 4, 5, 6, 7, 8, 9). As such, it seems likely that a certain danger-related ligand or ...
A large class of inflammasomes uses the protein ASC as its oligomerization unit (Cai et al., 2014, Lu et al., 2014). The PRRs NLRP1, NLRP3, NLRP6, AIM2, and Pyrin engage ASC through interactions between the pyrin domain on the receptor and the pyrin domain of ASC, resulting in olig...
n = 6–8. The comparison of protein expression was performed by Student's t-test. with 30 µg of proteins were prepared and separated by electrophoresis at 100 V for 2 hours at 4 °C in 10% poly- acrylamide gel (SDS-PAGE) and transferred for 1 hour to a ...
The bipartite inflammasome adaptor ASC plays a critical role in the NLRP3, AIM2 and NLRC4 inflammasomes15–18, but in-depth analysis of its role in NLRP1b inflammasome signalling was hampered by the LeTx- resistant phenotype of C57BL/6J mice. To characterize the role of ASC in NLRP1b ...
Other inflammasomes NLRP1 was the first inflammasome to be described and is activated following cleavage by the lethal toxin from Bacillus anthracis[13]. The NLRP1 inflammasome has its own CARD, so can bypass the requirement of the adapter molecule ASC for inflammasome activation (Figure 2). Clea...
. Low intracellular K+levels can activate NLRP1 and NLRP3 inflammasomes, thereby linking the non-canonical pathway to the canonical inflammasome pathway [212,213]. Caspase-11 can also be activated by a class of DAMPs known as oxidized 1-palmitoyl-2-arachidonyl-sn-glycero-3-phosphorylcholine (o...
Furthermore, the inflammasomes also play important roles in the induction of proper humoral immunity against HBV. A study by Weinberger et al., revealed that inflammasomes, especially NLRP1, NLRP3 and NLRP12, significantly participate in the induction of immune responses against hepatitis B surface ...
NLRP1 is also unique in that the adaptor protein ASC binds to the N-terminal PYD domain on NLRP1 to facilitate its connection to the CARD domain on procaspase-1. Although ASC-PYD binding can occur, an interaction with ASC may not be necessary for NLRP1 inflammasome activation, and an ...