Natural killer (NK) cells express many newly identified activating and inhibitory recep- tors that upon engagement by cognate ligands on target tumor cells regulate NK cell anti- tumor activity. Recently, several paired NK cell receptor families that include receptors with similar binding specificities...
The activation of natural killer (NK) cells depends on a change in the balance of signals from inhibitory and activating receptors. The activation threshold values of NK cells are thought to be set by engagement of inhibitory receptors during development. Here, we found that the activating recepto...
Some activating receptors and some inhibitory receptors are expressed on NK cells (and some other cell types), while other activating and inhibitory receptors are expressed on myeloid cells, dendritic cells (DC) and other cell types. In contrast, there are only a few such lectin-like receptor ...
First, NK cells may not traffic efficiently to the tumor site [17]. Second, if NK cells do infiltrate malignant lesions, they may not function properly because of lack of expression of functional NK cell activating signals by tumor cells and/or because of the presence of tumor-derived ...
NK cells are an important component of the innate immune system. Their activity is tightly regulated by activating and inhibitory surface receptors. However, the exact functions of many activating surface receptors, as well as their ligands, still remain to be elucidated. NTB-A is a receptor on...
The complex TME also impacts upon the activating and inhibitory receptors expressed by infiltrating NK cells and thus contribute to NK cell dysfunction. A number of different cell types in the TME, such as regulatory T cells, myeloid dervived suppressor cells and fibroblasts, and the immunosuppress...
The complex TME also impacts upon the activating and inhibitory receptors expressed by infiltrating NK cells and thus contribute to NK cell dysfunction. A number of different cell types in the TME, such as regulatory T cells, myeloid dervived suppressor cells and fibroblasts, and the immunosuppress...
NK cells are an important component of the innate immune system.Their activity is tightly regulated by activating and inhibitory surface receptors.However,the exact functions of many activating surface receptors,as well as their ligands,still remain to be elucidated.NTB-A is a receptor on the surfa...
Innate natural killer (NK) cells are diverse at the single-cell level because of variegated expressions of activating and inhibitory receptors, yet the developmental roots and functional consequences of this diversity remain unknown. Because NK cells are critical for antiviral and antitumor responses, ...
Although inhibitory molecules are believed to prevent the response against normal autologous cells, the role of their self-reactive activating counterparts is intriguing. A possibility is that KIR2DS/3DS and CD94/NKG2CReferences (108) W.M. Yokoyama Natural killer cell receptors Curr Opin Immunol (...