H., Inhibitory MHC class I receptors on NK cells and T cells. Immunol. Today 1996. 17: 86-91.Wu MY , Yang JH , Chao KH , Hwang JL , Yang YS , Ho HN . 2000 . Increase in the expression of killer cell inhibitory receptors on peritoneal natural killer cells in women with ...
A Sehgal,TL Whiteside,M Boyiadzis - 《Expert Opinion on Biological Therapy》 被引量: 28发表: 2015年 Overexpression of CD158 and NKG2A Inhibitory Receptors and Underexpression of NKG2D and NKp46 Activating Receptors on NK cells in Acute Myeloid Leukemia Natural killer (NK) cells are innate imm...
The effect of Ly49C/I receptors on NK cell-mediated cytotoxicity was tested as described in the legend to Figure 1B using sorted subsets of Ly49C+/I+ and Ly49C-/I- NK cells and are representative of 3 independent experiments. Data presented are the mean values of percent cytotoxicity ag...
Our results revealed no benefit of KIR-HLA mismatch and demonstrate that NKG2A+KIR− NK cells dominate the functional repertoire early after transplantation and that NK cells lacking inhibitory receptors for self HLA class I ligands remain tolerant at all time points in both settings. Methods ...
Relatively little is known about how MHC class I molecules affect expression of the Ly49 receptors. Through the analysis of the present MHC class I mosaic mice, we demonstrate that the expression levels of Ly49C on NK cells is a consequence not only of MHC class I expression in the ...
NK cells have to be “educated” to correctly fulfill their functions. The expression of inhibitory receptors (IR) must be regulated in a way such that NK cells remain tolerant towards normal autologous cells while recognizing and eliminating cells that have lost, in part or in total, the expr...
Inhibitory natural killer receptors (NKRs) such as killer cell immunoglobulin-like receptors (KIRs) in humans and Ly49 molecules in mice are expressed on NK cells and recognize multiple major histocompatibility (MHC) class I proteins. In humans and mice, a subset of CD8+ T cells also expresses...
NKG2A can also be expressed by activated CD8+ T cells, but at E9.5, there was no expression of NKG2A on T cells in the uterus or the spleen of WT B6 mice (Figure S1B). Therefore, in B6 mice, NKG2A is solely expressed on NK cells and not accompanied by other NKG2 receptors. In...
Inhibitory receptors on myeloid cells: New targets for therapy? Pharmacology & Therapeutics Volume 125, Issue 1, January 2010, Pages 128-137 Purchase options CorporateFor R&D professionals working in corporate organizations. Academic and personalFor academic or personal use only. Looking for a customize...
A Sehgal,TL Whiteside,M Boyiadzis - 《Expert Opinion on Biological Therapy》 被引量: 28发表: 2015年 Overexpression of CD158 and NKG2A Inhibitory Receptors and Underexpression of NKG2D and NKp46 Activating Receptors on NK cells in Acute Myeloid Leukemia Natural killer (NK) cells are innate imm...