Their function is finely regulated by an array of HLA﹕pecific and non〩LA﹕pecific inhibitory and activating receptors which allow to discriminate between healthy and altered cells. Human NK cells gained a major attention in recent years because of the important progresses in understanding their ...
CD56 bright NK cells were highly sensitive to AhR ligands. Specifically, AhR ligands modulated their activation and their expression of NK cell receptors, as well as cytokine secretion which is the major function of these cells. As CD56 bright NK cells are highly enriched in tissues and in ...
All ILCs lack rearranged antigen-specific receptors, yet they share many features with adaptive T cell subsets. NK cells express the transcription factors (TFs) T-BET and EOMES, produce interferon-γ (IFN-γ), and kill tumor and virally-infected cells (Sun and Lanier, 2011). ILC1s are T...
Asiaticoside-treated NK cells retained their ability to suppress tumor growth and metastasis despite TGF-β presence. Asiaticoside downregulated TGF-β receptors 1 (TGFBR1) expression, impaired the protein stability of TGFBR1 and TGF-β receptors 2 (TGFBR2), and reduced SMAD2 phosphorylation, prev...
Besides their role as tumor antigens, the ectodomains of the NKG2DLs can be shed from the plasma membrane of malignantly transformed cells and subsequently inhibit NKG2D-dependent NK cell cytotox- icity [19,20]. Importantly, tumor infiltration of NK cells co- incides with anti-tumor activity ...
Interaction between Human NK Cells and Bone MarrowInteraction between Human NK Cells and Bone MarrowReceptors, NkgdPoggi, AlessandroPrevosto, ClaudiaMassaro, AnnamariaNegrini, SimoneUrbani, SerenaPierri, IvanaSaccardi, RiccardoGobbi, MarcoZocchi, Maria Raffaella...
MicroRNA transcriptomes of distinct human NK cell populations identify miR-362-5p as an essential regulator of NK cell function Fang Ni1,2*, Chuang Guo1*, Rui Sun1, Binqing Fu1,3, Yue Yang2, Lele Wu2, Sitong Ren2, Zhigang Tian1,3 & Haiming Wei1 1Institute of Immunology and the ...
To address these issues, we determined (i) if large numbers of NK cells could be expanded from PBMC and GMP compliant cell fractions derived by elutriation, (ii) their ability to kill allogeneic and autologous tumor targets by direct cytotoxitiy and by antibody-mediated cellular cytotoxicity and...
To address these issues, we determined (i) if large numbers of NK cells could be expanded from PBMC and GMP compliant cell fractions derived by elutriation, (ii) their ability to kill allogeneic and autologous tumor targets by direct cytotoxitiy and by antibody-mediated cellular cytotoxicity and...
Natural killer (NK) cells are innate lymphoid cells important for host defense against pathogens and mediate antitumor immunity. Cytokine receptors transduce important signals that regulate proliferation, survival, activation status, and trigger effector functions. Here, we review the roles of major cytoki...