Their function is finely regulated by an array of HLA﹕pecific and non〩LA﹕pecific inhibitory and activating receptors which allow to discriminate between healthy and altered cells. Human NK cells gained a major attention in recent years because of the important progresses in understanding their ...
Innate natural killer (NK) cells are diverse at the single-cell level because of variegated expressions of activating and inhibitory receptors, yet the developmental roots and functional consequences of this diversity remain unknown. Because NK cells are critical for antiviral and antitumor responses, ...
To address these issues, we determined (i) if large numbers of NK cells could be expanded from PBMC and GMP compliant cell fractions derived by elutriation, (ii) their ability to kill allogeneic and autologous tumor targets by direct cytotoxitiy and by antibody-mediated cellular cytotoxicity and...
Function of γδ T cells in tumor immunology and their application to cancer therapy Article Open access 12 March 2021 Introduction γδT cells, which are innate-like T lymphocytes characterized by T-cell receptors (TCRs) composed of γ and δ chains, are widely distributed in the periphera...
Natural killer (NK) cells are innate lymphocytes that can directly kill target cells without any prior exposure while not damaging healthy “self” cells. Unlike T and B cells that recognize antigen through clonally distributed, somatically rearranged receptors, NK cells recognize their targets through...
Regulatory role of NKp44, NKp46, DNAM-1 and NKG2D receptors in the interaction between NK cells and trophoblast cells. Evidence for divergent functional profiles of decidual versus peripheral NK cells. Int Immunol 2008; 20: 1395–1405. Article CAS Google Scholar Karimi K, Arck PC . Natural...
To address these issues, we determined (i) if large numbers of NK cells could be expanded from PBMC and GMP compliant cell fractions derived by elutriation, (ii) their ability to kill allogeneic and autologous tumor targets by direct cytotoxitiy and by antibody-mediated cellular cytotoxicity and...
In addition to NK cells, these receptors can be expressed on T cell subsets, mainly on CD8+ T cells but also on γδTCR+ T cells and CD4+ T cells. Although the function of NK cell receptor expression on T cells is not completely understood, various studies have shown that they are ...
NK cells were originally identified based on their ability to kill tumor target cells in the absence of prior sensitization [1,2], distinguishing them from adaptive T cells. Over the past 4 decades, it has become clear that NK cells perform more functions than “natural killing” and participa...
In addition to their cytotoxic function, NK cells can either suppress or enhance Ab production. Upon activation, NK cells generally amplify Ig secretion by activated B cells. We now report that activated NK cells prepared from human peripheral blood can induce resting B cells to produce IgM and...