Lanier LL.On guard—activating NK cell receptors.Nature Immunology. 2001Lanier, L. L. 2001. On guard-activating NK cell receptors. Nat. Immunol. 2:23.Lanier, L. L. 2001. On guard--activating NK cell receptors. Nat. Immunol. 2: 23-27....
Here we discuss CD160 an essential NK cell activating receptor that remains poorly understood. CD160 receptor exhibits a number of unique structural and functional characteristics that are not common to other killer immunoglobulin-like receptors that recognize major histocompatibility complex (MHC) class ...
The activation of natural killer (NK) cells depends on a change in the balance of signals from inhibitory and activating receptors. The activation threshold values of NK cells are thought to be set by engagement of inhibitory receptors during development
Activating NK-cell receptors co-stimulate CD4 doi:10.1002/eji.200939399European Journal of ImmunologyFasth, Andreas E. R.Bjrkstrm, Niklas K.Anthoni, MinnaMalmberg, Karl-JohanMalmstrm, Vivianne
Cell expansion shifted the NK cell receptor repertoire towards activation and resulted in cytotoxicity against various allogeneic tumor cell lines and autologous gastric cancer cells, while sparing normal PBMC. Blocking studies confirmed that autologous cytotoxicity is established through multiple activating rec...
NK cells can express a variety of activating and inhibitory receptors including killer inhibitory receptor (KIR), and killer lectin like receptor (KLR) and natural cytotoxic receptors (NCR). NK cells and their receptors play roles in various facets of transplantation, disease, pregnancy and control...
ADCC效应机制 当IgG抗体通过Fab段与靶细胞（病毒感染的细胞或肿瘤细胞）表面抗原决定簇特异性结合后，其Fc段可与有FcγR受体的效应细胞（NK细胞、单核-巨噬细胞、中性粒细胞等）结合，触发效应细胞的杀伤活性，直接杀伤靶细胞。NK细胞有慧眼 NK细胞表面有众多受体，分为激活性受体Activating receptors和抑制性受体...
On guard?activating NK cell receptors. Although natural killer (NK) cells are known to preferentially kill cells that lack major histocompatibility complex class I antigens, we do not know what ... Lanier,Lewis,L. - 《Nature Immunology》 被引量: 461发表: 2001年 The response to and repair ...
Here we discuss CD160 an essential NK cell activating receptor that remains poorly understood. CD160 receptor exhibits a number of unique structural and functional characteristics that are not common to other killer immunoglobulin-like receptors that recognize major histocompatibility complex (MHC) class ...
It has become clear that the biologic activity of NK cells is controlled by a complex repertoire of surface receptors which, upon engagement by ligands on a target cell, signal either an inhibitory or activating response [6]. The major inhibitory and activating receptors are products of germ lin...