The cells tested expressed genes encoding VDR and enzymes that activate or inactivate vitamin D(3). Novel secosteroids show potent anti-melanoma activity ... AT Slominski,Z Janjetovic,TK Kim,... - 《Anticancer Research》 被引量: 109发表: 2012年 Procathepsin-L, a proteinase which cleaves ...
PROBLEM TO BE SOLVED: To provide immune system cells of a sufficient number capable of being used in immune cell therapy.SOLUTION: The present invention relates to a method by which cells that can be used in immune cell therapy are separated from peripheral blood and propagated.阿部 博幸...
Natural killer (NK) cells play an important role in host defense against viral infections and malignancy, and their role for regulating other components of the antiviral response is being investigated. In this issue of the JCI, Ali et al. examine the mechanisms by which NK cells migrate into ...
However, it is also well established that growth-stimulating signals feed back into growth-suppressing pathways, and any imbalance in these signaling networks will cause the cell to exit the cell cycle, thereby preventing uncontrolled cell growth. How, then, do K-RAS-activated cells evade cellular...
Learn why beneficial gut bacteria are essential for healthy aging, and how to feed them the right nutrition. Schematic representation of physiological, nutritional and immune targets of intervention generally identified for elderly people. MUFA: mono-unsaturated fatty acids; NK: natural killer cells. ...
This study identifies NKT1, NKT2 and NKT17 thymic NKT cells, providing evidence that not all NK1.1– NKT cells are precursors to NK1.1+ NKT cells. CAS PubMed Google Scholar Engel, I. et al. Innate-like functions of natural killer T cell subsets result from highly divergent gene ...
All of these different types of cells have their own specialized niche in the innate immune response. Some are antigen-presenting cells (APCs), such as macrophages and dendritic cells, that present an identifying molecule from a pathogen on their surface toT cellsto activate the adaptive immune ...
As the ambient temperature fluctuates, plants detect these shifts and dispatch signaling molecules to activate downstream pathways. They subsequently rely on a cascade of intricate molecular mechanisms to orchestrate physiological and biochemical adjustments, thereby responding to temperature variations. This ad...
Large granular lymphocytic leukemia (LGLL) represents a rare neoplasm of mature T cells or natural killer (NK) cells, with an indolent clinical course. Diagnosing LGLL can be challenging because of overlapping features with reactive processes and other mimickers. Methods By presenting 2 challenging ca...
Why are stem cells necessary for cell differentiation? How does the target cell killing by the NK cells occur? Why do complex organisms need specialized cells? How do viruses attach themselves to host cells? How do dendritic cells activate T cells?