NK cell-depleted PBMCs had increased ADE as compared to whole PBMCs. Conversely, adding activated NK cells back into the NK-depleted-PBMCs or to purified monocytes decreased ADE. Blocking IFN-纬 expression also increased ADE. The study suggests that under ADE conditions, NK cells can be ...
Martin, et al., CD56negCD16(+) NK cells are activated mature NK cells with impaired effector function during HIV-1 infection, Retrovirology 10 (2013) 158.JM Milush, S Lopez-Verges, VA York, SG Deeks, JN Martin, FM Hecht, LL Lanier and DF Nixon. CD56negCD16(+) NK cells are ...
transient lymphocytes that promote decidualization, including immune tolerance and vascular development26,27,28,29. Unlike human peripheral NK (CD56dim), decidual NK (dNK) cells (CD56bright) are non-cytotoxic cells with angiogenic potential that appear to be essential for normal early ...
In mouse models of chronic inflammatory diseases, Natural Killer (NK) cells can play an immunoregulatory role by eliminating chronically activated leukocytes. Indirect evidence suggests that NK cells may also be immunoregulatory in humans. Two subsets of
This was demonstrated by adding IL-2 or pokeweed mitogen to purified NK cells and B cells. The addition of IL-2-activated NK cells to B cells also had this effect. The responding B cells did not require activation. Moreover, following fractionation of B cells on Percoll gradients, ...
NK cell percentages and monocyte polarization as the TPO-Ab+ PPTD+ cases, but they had normal percentages of activated peripheral T cells and a lower ... Johannes L. Kuijpens,MD Hann-Meulman,Huib L. Vader,... - 《J Clin Endocrinol Metab》 被引量: 481发表: 1998年 Vitamin D and the...
FIBRONECTIN EXPRESSION BY ENDOGENOUS AND ACTIVATED NK CELLS S. Morrone, S. Scarpa, R. Testi, G. D'Orazi, A. Gismondi, A. Punturieri, M. Piccoli, L. Frati, A. Modesti Dipartimento di Medicina Sperimentale, Università "La Sapienza" Roma, Italy A. Santoni Dipartimento di Scienze e Tecno...
The graft-versus-tumor (GVT) effect was retained in the presence of donor NK cells. We demonstrate a novel mechanism of NK cell–mediated GVHD reduction whereby donor NK cells inhibit and lyse autologous donor T cells activated during the initiation of GVHD....
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Thus, our findings reveal new fundamental aspects of the NKT-NK cell axis that provide important hints for the manipulation of NK cells in clinical settings. 展开 关键词: NK-cell differentiation NK-cell education NKT cells mCMV αGalCerMPEG ...