Saudemont A, Jouy N, Hetuin D, Quesnel B (2005) NK cells that are activated by CXCL10 can kill dormant tumor cells that resist CTL-mediated lysis and can express B7-H1 that stimulates T cells. Blood 105:2428-2435Saudemont A,,Jouy N,Hetuin D,et al.NK cells that are activated by...
Thus, our findings reveal new fundamental aspects of the NKT-NK cell axis that provide important hints for the manipulation of NK cells in clinical settings. 展开 关键词: NK-cell differentiation NK-cell education NKT cells mCMV αGalCerMPEG ...
This was demonstrated by adding IL-2 or pokeweed mitogen to purified NK cells and B cells. The addition of IL-2-activated NK cells to B cells also had this effect. The responding B cells did not require activation. Moreover, following fractionation of B cells on Percoll gradients, ...
transient lymphocytes that promote decidualization, including immune tolerance and vascular development26,27,28,29. Unlike human peripheral NK (CD56dim), decidual NK (dNK) cells (CD56bright) are non-cytotoxic cells with angiogenic potential that appear to be essential for normal early ...
Roberti MP, Rocca YS, Amat M, et al: IL‑2‑ or IL‑15‑activated NK cells enhance Cetuximab‑mediated activity against triple‑negative breast cancer in xenografts and in breast cancer patients. Breast Cancer Res Treat 136: 659‑671, 2012....
Furthermore, cross-linking of NKp46 by NKp46-specific mAbs led to a superior CD107a expression in the NKp46high NK cells, thus indicating a higher cytolytic capacity of this subset. Therefore porcine splenic NKp46high NK cells represent a highly activated subset of NK cells and may play a...
Furthermore, CD7+CD56negCD16+ NK cells have significantly increased expression of CD95, a marker of NK cell activation. Conclusions Taken together, CD7+CD56negCD16+ NK cells are activated, mature NK cells that may have recently engaged target cells. 展开 ...
The graft-versus-tumor (GVT) effect was retained in the presence of donor NK cells. We demonstrate a novel mechanism of NK cell-mediated GVHD reduction whereby donor NK cells inhibit and lyse autologous donor T cells activated during the initiation of GVHD. 展开 ...
In mouse models of chronic inflammatory diseases, Natural Killer (NK) cells can play an immunoregulatory role by eliminating chronically activated leukocytes. Indirect evidence suggests that NK cells may also be immunoregulatory in humans. Two subsets of
The graft-versus-tumor (GVT) effect was retained in the presence of donor NK cells. We demonstrate a novel mechanism of NK cell–mediated GVHD reduction whereby donor NK cells inhibit and lyse autologous donor T cells activated during the initiation of GVHD....