NK细胞的招募和活化与敲除鼠类似。 为了达到更好的治疗效果,作者探究了boost any feature of NK cell immunity是否可以增强TREM2 blockade的抗肿瘤效果。因此作者加入了agents that release the breaks on NK cell activation, by preventing the degradation of NK cell-activating ligands. Fig 5C:联合治疗效果更好 ...
正常的机体组织细胞MHC I类分子与NK细胞表面的杀伤细胞免疫球蛋白样受体(killer cell immnoglobulin-like receptor,KIR)结合产生抑制信号,避免了NK对自身健康细胞的误伤,根据以往的临床研究结果,回输应用NK细胞没有发现不良副作用[26],已具备了作为临床...
Cytokine and chemokine release follows a different secretory pathway which also requires phospholipase C-纬 activation and store-operated Ca+ entry. Recent studies of human NK cells have provided insights into...
正常的机体组织细胞MHC I类分子与NK细胞表面的杀伤细胞免疫球蛋白样受体(killer cell immnoglobulin-like receptor,KIR)结合产生抑制信号,避免了NK对自身健康细胞的误伤,根据以往的临床研究结果,回输应用NK细胞没有发现不良副作用[26],已具备了作为临床应用的安全性和有效性。 图片来自文献28 据报道,已有多项NK细胞...
.24–26 Given that NK cells from either 2B4 knockout mice or CD48 knockout mice fail to reject CD48-deficient tumor cells,24,27 this 2B4-CD48 engagement is necessary for NK cell- mediated recognition of missing self-CD48 targets and thus represents a MHC-I-independent education pathway. ...
正常的机体组织细胞MHC I类分子与NK细胞表面的杀伤细胞免疫球蛋白样受体(killer cell immnoglobulin-like receptor,KIR)结合产生抑制信号,避免了NK对自身健康细胞的误伤,根据以往的临床研究结果,回输应用NK细胞没有发现不良副作用[26],已具备了作为临床应用的安全性和有效性。
NK cells can also express other inhibitory receptors which function as IC of NK cell activation, including PD-1, TIGIT, CD96, TIM-3 and CD161 (Sivori et al., 2019b). Some of these receptors are not constitutively expressed by resting NK cells, but they may be induced/upregulated under...
and its protein expression is decreased in METTL3-deficient NK cells. Reduced SHP-2 activity renders NK cells hyporesponsive to IL-15, which is associated with suppressed activation of the AKT and MAPK signaling pathway in...
Finally, at least in some setting, hypoxia causes mitochondrial fragmentation in NK cells via a pathway involving constitutive mechanistic target of rapamycin (MTOR) signaling and consequent activation of dynamin 1 like (DNM1L, best known as DRP1), resulting in a shift from oxidative phosphorylation...
R. Modulation of natural killer cell anti-tumor reactivity by platelets. J. Innate Immun. 3, 374–382 (2011). Article CAS PubMed Google Scholar Wilson, E. B. et al. Human tumour immune evasion via TGF-β blocks NK cell activation but not survival allowing therapeutic restoration of anti...