Unlike cells of the adaptive immune response, NK cells do not recognize specific antigens expressed on MHC receptors, rather they recognize tumorgenic and virally infected cells through a complex balance of activating and inhibiting receptors expressed on both cell surfaces. Lectin-like transcript 1 ...
The activation of natural killer (NK) cells depends on a change in the balance of signals from inhibitory and activating receptors. The activation threshold values of NK cells are thought to be set by engagement of inhibitory receptors during development. Here, we found that the activating recepto...
The CD160–Fc fusion protein was shown to bind to H2Dd, H2Db, H2Kb, Qa-1b, and CD1d to varying degrees [6], but interaction between murine CD160 and mouse MHC class I is weaker than other NK cell receptors [4]. Both activating and inhibitory functions have been attributed to CD160...
Cell expansion shifted the NK cell receptor repertoire towards activation and resulted in cytotoxicity against various allogeneic tumor cell lines and autologous gastric cancer cells, while sparing normal PBMC. Blocking studies confirmed that autologous cytotoxicity is established through multiple activating rec...
On guard?activating NK cell receptors. Although natural killer (NK) cells are known to preferentially kill cells that lack major histocompatibility complex class I antigens, we do not know what ... Lanier,Lewis,L. - 《Nature Immunology》 被引量: 461发表: 2001年 The response to and repair ...
NK cell receptors/ligands axes56,57,58. Here we demonstrated a different approach using engineeredSalmonellato efficiently drive NK cells into a subtype with high anti-metastatic activity characterized by higher expression of phenotypic and activated markers including CD11b, CD11c, CD38, and NKG2D. In...
In addition to domains derived from receptors expressed in T cells, domains from NK cell receptors have also been incorporated into CAR constructs to improve NK cell activation (Fig.1). Several NK cell receptors have been shown to replace the extracellular recognition domain, the transmembrane regio...
(ii) activation receptors and other cell surface structures that mediate target cell killing are increasingly expressed on the expanded NK cells, (iii) NK cells expanded from PBMC from patients with solid tumors kill allogeneic and autologous cancer cell lines by direct cytotoxicity and, importantly,...
(ii) activation receptors and other cell surface structures that mediate target cell killing are increasingly expressed on the expanded NK cells, (iii) NK cells expanded from PBMC from patients with solid tumors kill allogeneic and autologous cancer cell lines by direct cytotoxicity and, importantly,...
NK cell depletion or inhibition of the NK cell activation receptors (NKp46 or FcɣRIIIa) started at E11.5. Intraperitoneal injection of 50 µl of undiluted anti-asialo-GM-1 serum was used for NK cell depletion at E11.5 and E14.5 (n = 8). Anti-NKp46 (3.33 mg per kg ...