近期,韩国生物科学与生物技术研究院免疫治疗研究中心的研究团队在著名期刊《Nature immunology》发表了题为“NgR1 is an NK cell inhibitory receptor that destabilizes the immunological synapse”的文章,他们报道了一种新型的NK细胞抑制性受体Nogo...
近期,韩国生物科学与生物技术研究院免疫治疗研究中心的研究团队在著名期刊《Nature immunology》发表了题为“NgR1 is an NK cell inhibitory receptor that destabilizes the immunological synapse”的文章,他们报道了一种新型的NK细胞抑制性受体Nogo受体1(NgR1),它通过干扰接触稳定性和调节IS形成来影响NK细胞对表达Nogo...
近日,韩国生物科学与生物技术研究院免疫治疗研究中心的Tae-Don Kim教授团队在《nature immunology》上发表题为“NgR1 is an NK cell inhibitory receptor that destabilizes the immunological synapse” 的研究型长文(图1),他们详细报道了NgR1通过干扰接触稳定性和调节IS形成来影响NK细胞对表达NogoA靶细胞的杀伤能力。
Vivier E, Anfossi N (2004) Inhibitory NK-cell receptors on T cells: witness of the past, actors of the future. Nat Rev Immunol 4: 190-198.E. Vivier, N. Anfossi, Inhibitory NK-cell receptors on T cells: witness of the past, actors of the future, Nat. Rev. Immunol. 4 (2004) ...
近日,韩国生物科学与生物技术研究院免疫治疗研究中心的Tae-Don Kim教授团队在《nature immunology》上发表题为“NgR1 is an NK cell inhibitory receptor that destabilizes the immunological synapse”的研究型长文(图1),他们详细报道了NgR1通过干扰...
Sino Biological offers a range of related reagents including:NKG2D / CD314 / KLRK1,KLRG1,KIR3DL1,KIR2DL4 / CD158D,KIR2DL1 / CD158a,NCR1 / NK-p46,NCR2/NKp44 /CD336, andNCR3 (CD337), etc. NK Cell Receptors * Being developed. Tell us your requirement so that the products of int...
Natural killer cell function is controlled by interaction of NK receptors with MHC I molecules expressed on target cells. We describe the binding of bacterially expressed Ly49A, the prototype murine NK inhibitory receptor, to similarly engineered H-2Dd. Despite its homology to C-type lectins, Ly...
T-cell receptor (TCR) signaling plays a role in the activation of the stem cell transcriptional program in memory T cells;49 however, its effect on NK cell receptors needs further investigation. POSSIBLE MECHANISMS INVOLVED IN NK CELL MEMORY How NK cells gain memory remains unclear. In the ...
Furthermore, under the same coculture conditions, NK cell-mediated purging of C1498 leukemia cells contaminating syngeneic BMCs was more effective with inhibitory-receptor blockade, leading to a significantly higher proportion of animals with long-term survival compared to the control recipients. These ...
Most NK cell inhibitory receptors recognize MHC class I molecules, which are expressed by almost all nucleated cells. The binding of MHC class I complexes to killer cell Ig-like receptors (KIRs) or to the C-lectin-type heterodimeric CD94/NKG2A receptor, initiates inhibitory pathways that can ...