间充质干细胞源性外泌体(MSC-derived exosomes)是MSCs旁分泌作用的主要物质,也是目前研究和应用最广泛的外泌体之一。其包含与MSCs类似治疗性的生长因子及mRNA等生物活性物质,具有组织修复、免疫调节等疗效,同时又具备独特的优势,如:无自我复制能力,所以没有致瘤性;纳米级体积避免毛细血管截留,可以通过血脑屏障到达中...
Concise Review: MSC-Derived Exosomes for Cell-Free Therapy. Stem Cells 35: 851-858, 2017.Phinney, D. G., and Pittenger, M. F. (2017). Concise review: MSC-derived exosomes for cell-free therapy. Stem Cells 35, 851-858. doi: 10.1002/stem.2575...
MSCs produce multiple extracellular vesicles (EVs): exosomes (30–150 nm in diameter), microvesicles (150–500 nm in diameter), and apoptotic bodies (800–500 nm in diameter). EVs are thought to serve as paracrine mediators between MSCs and their target cells [11,12]. In addition, MSC-de...
Scaffolds can regulate the cell’s physical, chemical, and mechanical maintenance, as they are similar in structure to the ECM [44,45]. Scaffolds must be cytocompatible to attach well to cells to protect better and stabilize MSCs and MSC-derived exosomes through appropriate interactions such as c...
www.nature.com/cddis ARTICLE OPEN HucMSC-derived exosomes delivered BECN1 induces ferroptosis of hepatic stellate cells via regulating the xCT/GPX4 axis Youwen Tan1,4, Yan Huang2,3,4, Rong Mei2, Fei Mao 2, Dakai Yang2, Jinwen Liu2, Wenrong Xu2, Hui Qian2 ✉ and Yongmin Yan 1,2 ...
The present study demonstrated that exosomes derived from human umbilic cord msenchyma stem cells (hUC-MSC-EXO) has a therapeutic effect on pulmonary hypertension via inhibiting pulmonary vascular remodeling. Our conclusion is based on the following results. Abstract Background Pulmonary hypertension (PH...
Furthermore, it might be possible to harvest exosomes from supernatants of immortalized MSC cell lines, which otherwise could not be used for cellular therapies. Given the history of a therapy-refractory GvHD patient (Supplementary Figure S1), we decided to treat the patient in an individual ...
CGMP-Compliant Isolation and Development of MSC-Derived Exosomes Learn More Experience an Innovative Biotechnology Product Explore the Benefits of MSC-Derived Exosomes at Kimera Labs At Kimera Labs, we’re committed to providing cutting-edge clinical solutions to healthcare providers through up-to-date...
MSC-derived exosomes: a novel tool to treat therapy-refractory graft-versus-host disease. MSC-derived exosomes: A novel tool to treat therapy-refractory graft-versus-host disease. Leukemia, 28(4), 970.Kordelas L, Rebmann V, Ludwig AK, ... Kordelas,L,Rebmann,... - 《Leukemia》 被引量...
CGMP-Compliant Isolation and Development of MSC-Derived Exosomes Learn More Experience an Innovative Biotechnology Product Explore the Benefits of MSC-Derived Exosomes at Kimera Labs At Kimera Labs, we’re committed to providing cutting-edge clinical solutions to healthcare providers through up-to-date...