Our objective was to test the hypothesis that MSC-derived exosomes from non-treated MSC can mediate cardioprotection via specific miR cargo. To test this hypothesis, we identified by next generation RNA sequencing, the miRs present in exosomes isolated from murine MSC. We identified both protective...
CGMP-Compliant Isolation and Development of MSC-Derived Exosomes Learn More Experience an Innovative Biotechnology Product Explore the Benefits of MSC-Derived Exosomes at Kimera Labs At Kimera Labs, we’re committed to providing cutting-edge clinical solutions to healthcare providers through up-to-date...
CGMP-Compliant Isolation and Development of MSC-Derived Exosomes Learn More Experience an Innovative Biotechnology Product Explore the Benefits of MSC-Derived Exosomes at Kimera Labs At Kimera Labs, we’re committed to providing cutting-edge clinical solutions to healthcare providers through up-to-date...
间充质干细胞源性外泌体(MSC-derived exosomes)是MSCs旁分泌作用的主要物质,也是目前研究和应用最广泛的外泌体之一。其包含与MSCs类似治疗性的生长因子及mRNA等生物活性物质,具有组织修复、免疫调节等疗效,同时又具备独特的优势,如:无自我复制能力,所以没有致瘤性;纳米级体积避免毛细血管截留,可以通过血脑屏障到达中...
MSCs and MSC-derived exosomes: focus on wound healing Biomimetic scaffolds for delivery of MSCs and MSC-derived exosomes Biomimetic scaffolds combination with MSCs or MSC-derived exosomes: role in wound healing Future prospective Conclusion Data availability Abbreviations References Acknowledgements Funding Au...
The microRNA regulatory landscape of MSC-derived exosomes: a systems view. Sci Rep. 2018; 8(1):1419.Ferguson SW, Wang J, Lee CJ, et al. The microRNA regulatory landscape of MSC-derived exosomes: a sys- tems view. Sci Rep. 2018;8(1):1419....
While many studies describe exosomes as deriving from multivesicular bodies, solid evidence about the origin of EVs is often lacking. Extracellular vesicles represent an important portion of the cell secretome. Their numerous properties can be used for diagnostic, prognostic, and therapeutic uses, so ...
the lipid membrane of exosomes serves not only to protect exosome proteins and RNA from degradation, but also allows exosomes to reach cells in parts of the body that many drugs cannot. For example, exosomes are able to cross the blood-brain barrier and can penetrate solid tissue masses like...
In addition, MSC-derived exosomes (MSC-Exos) can recapitulate the biological potential of MSCs; therefore, they may substitute for cell therapy to achieve cell-free therapy [13, 14]. The advantages of exosome utilization, when compared to their cellular counterparts, include a higher safety ...
Msenchymal stem cells-derived exosomes have been shown to have significant therapeutic effects in PH, however, the mechanism still very blurry. Here, we investigated the possible mechanism by which umbilical cord mesenchymal stem cell-derived exosomes (hUC-MSC-EXO) inhibited monocrotaline (MCT)-...