这些研究将进一步增强MSC-Exos作为一种新的疾病治疗方法的潜力。 参考文献:Lotfy A, AboQuella NM, Wang H. Mesenchymal stromal/stem cell (MSC)-derived exosomes in clinical trials. Stem Cell Res Ther. 2023 Apr 7;14(1):66. doi: 10.1186/s13287-023-03287-7. PMID: 37024925; PMCID: PMC10079493....
Compared to MSCs themselves, MSC-derived exosomes (MSC-Exos) have provided significant advantages by efficiently decreasing unfavorable adverse effects, such as infusion-related toxicities. MSC-Exos is becoming a promising cell-free therapeutic tool and an increasing number of clinical studies started ...
Lotfy, A., AboQuella, N.M. & Wang, H. Mesenchymal stromal/stem cell (MSC)-derived exosomes in clinical trials. Stem Cell Res Ther 14, 66 (2023). https://doi.org/10.1186/s13287-023-03287-7.
干细胞来源细胞外囊泡MSC-EVs在疾病治疗、食品及临床进展中的应用 细胞外囊泡(extracellular vesicles, EVs)/外泌体(exosomes)是几乎所有细胞在其生命活动中分泌的一种具有生物膜结构的纳米尺度的小囊泡。作为细胞间通讯的一种途径,广泛参与并调控着生命机体的多种生理和病理过程(图1)。外泌体独特的物理和生化性质...
Compared to MSCs themselves, MSC-derived exosomes (MSC-Exos) have provided significant advantages by efficiently decreasing unfavorable adverse effects, such as infusion-related toxicities. MSC-Exos is becoming a promising cell-free therapeutic tool and an increasing number of clinical studies started ...
Therefore, UC-MSCs, one of the most widely applied MSCs in clinical trials, were used to produce exosomes, the function of which was explored in our study [23]. In the present study, we investigated the protective effect of MSC-derived exosomes on hair cells in a neomycin-induced SNHL ...
Application of MSC Exosomes in Clinical Medicine Ongoing research into MSC Exosomes presents a tremendous opportunity for development of biopharmaceuticals by providing a simple mechanism for delivery of therapeutic molecules. Preclinical studies indicate that the naturally occurring proteins, messenger RNA and...
Exosomes function as intercellular communication vehicles to transfer bioactive molecules (based on their origins), between cells. In this review, the recent exosome-based clinical trials for the treatment of COVID-19 are presented. Potential therapy may include the following items: First, using ...
Activated hepatic stellate cells (HSCs) are significant in liver fibrosis. Our past investigations have shown that human umbilical cord mesenchymal stem cells (hucMSCs) and their secreted exosomes (MSC-ex) could alleviate liver fibrosis via restraining H
Comparison of exosomes secreted by induced pluripotent stem cell-derived mesenchymal stem cells and synovial membrane-derived mesenchymal stem cells for the treatment of osteoarthritis. Stem Cell Res Ther. 2017;8(1):64. Article PubMed PubMed Central Google Scholar Zhang S, Chuah SJ, Lai RC, ...