这些研究将进一步增强MSC-Exos作为一种新的疾病治疗方法的潜力。 参考文献:Lotfy A, AboQuella NM, Wang H. Mesenchymal stromal/stem cell (MSC)-derived exosomes in clinical trials. Stem Cell Res Ther. 2023 Apr 7;14(1):66. doi: 10.1186/s13287-023-03287-7. PMID: 37024925; PMCID: PMC10079493....
Lotfy, A., AboQuella, N.M. & Wang, H. Mesenchymal stromal/stem cell (MSC)-derived exosomes in clinical trials. Stem Cell Res Ther 14, 66 (2023). https://doi.org/10.1186/s13287-023-03287-7.
bone marrow, or umbilical cord are used as sources of exosomes in 21 registered clinical trials. While bone marrow is the most popular source of MSC-Exos in preclinical studies [41], adipose tissue is the most frequently used source in clinical studies, as they have been used ...
干细胞来源细胞外囊泡MSC-EVs在疾病治疗、食品及临床进展中的应用 细胞外囊泡(extracellular vesicles, EVs)/外泌体(exosomes)是几乎所有细胞在其生命活动中分泌的一种具有生物膜结构的纳米尺度的小囊泡。作为细胞间通讯的一种途径,广泛参与并调控着生命机体的多种生理和病理过程(图1)。外泌体独特的物理和生化性质...
1、Mesenchymal stromal/stem cell (MSC)-derived exosomes in clinical trials https://stemcellres.biomedcentral.com/articles/10.1186/s13287-023-03287-7 2、Nojehdehi, S.; Soudi, S.; Hesampour, A.; Rasouli, S.; Soleimani, M.; Hashemi, S.M. Immunomodulatory effects of mesenchymal stem cell...
Compared to MSCs themselves, MSC-derived exosomes (MSC-Exos) have provided significant advantages by efficiently decreasing unfavorable adverse effects, such as infusion-related toxicities. MSC-Exos is becoming a promising cell-free therapeutic tool and an increasing number of clinical studies started ...
Concise Review: MSC-Derived Exosomes for Cell-Free Therapy. Stem Cells 35: 851-858, 2017.Phinney, D. G., and Pittenger, M. F. (2017). Concise review: MSC-derived exosomes for cell-free therapy. Stem Cells 35, 851-858. doi: 10.1002/stem.2575...
“exosomes.” Exosomes are a subtype of extracellular vesicle (EV) with a diameter in the range of 40–150 nm. Such vesicles are typically secreted by several sorts of cells, most importantly, stem/stromal cells, immune cells, or tumor cells [85]. Exosomes contain various biological ...
Investigation of the biological effects of MSC exosomes with laboratory studies and clinical trials should be performed to demonstrate the safety and efficacy of exosome-based therapy for cardiovascular, neurologic, musculoskeletal and dermatologic conditions and more. ...
We had previously reported the efficacy of MSC exosomes in the repair and regeneration of osteochondral defects at 6 and 12 weeks [18]. To better understand the kinetics of this repair, we repeated the study using more rats and included an earlier time point of 2 weeks (Fig. 1A). In thi...