目前研究发现,OE-MSCs可以作为一个有效的治疗工具应用于多种疾病模型。外泌体(exosomes)是一种由细胞分泌至胞外直径约为 30nm~100nm的分泌性囊泡。研究表明exosomes能够把自身所携带的蛋白和RNA分子传递给受体细胞,从而对靶细胞的生物学功...
MSC细胞外泌体是无血清培养人脐带间充质干细胞上清液中分离提取获得的高纯度外泌体颗粒,直径在30 - 150 nm,可作为科研试剂用于透射电镜分析、NTA粒径分析、核酸蛋白分析、细胞学及动物学实验等。 组分信息 组分名称 41220ES60 MSC细胞外泌体(人) 100 μg 储存条件 -80℃保存,有效期9个月 。 使用说明 产...
Understanding the principal cellular and biochemical mechanisms of disease and injury and how MSC exosomes could influence cellular behavior opens the door for research and development of the next generation of diagnostic modalities and therapeutic biologics. ...
The efficacy of mesenchymal stem cell (MSC) therapies is increasingly attributed to paracrine secretion, particularly exosomes. In this study, we investigated the role of MSC exosomes in the regulation of inflammatory response, nociceptive behaviour, and condylar cartilage and subchondral bone healing in...
[11,12]. In addition, MSC-derived exosomes (MSC-Exos) can recapitulate the biological potential of MSCs; therefore, they may substitute for cell therapy to achieve cell-free therapy [13,14]. The advantages of exosome utilization, when compared to their cellular counterparts, include a higher ...
Mesenchymal stem cell (MSC) exosome was previously shown to be effective in repairing critical size osteochondral defects in an immunocompetent rat model. Here we investigate the cellular processes modulated by MSC exosomes and the mechanism of action underlying the exosome-mediated responses in cartilag...
Furthermore, it might be possible to harvest exosomes from supernatants of immortalized MSC cell lines, which otherwise could not be used for cellular therapies. Given the history of a therapy-refractory GvHD patient (Supplementary Figure S1), we decided to treat the patient in an individual ...
MSC-exosomes in regenerative medicinedoi:10.1016/B978-0-12-816053-4.00019-5Yueyuan Zhou a bNobuyoshi Kosaka a dZhongdang Xiao bTakahiro Ochiya a cExosomes
Explore the Benefits of MSC-Derived Exosomes at Kimera Labs At Kimera Labs, we’re committed to providing cutting-edge clinical solutions to healthcare providers through up-to-date research and development procedures and comprehensive clinical investigation. ...