Mesenchymal stem cells (MSCs) isolated from Wharton's jelly (WJ-MSCs) and adipose tissue (AD-MSCs) are alternative sources for bone marrow-derived MSCs. Owing to their multiple functions in angiogenesis, immune modulation, proliferation, migration, and nerve regeneration, MSC-deriv...
Human umbilical cord Wharton's jelly-derived MSCs IBMX: Isobutylmethylxanthine KEGG: Kyoto encyclopaedia of genes and genomes MSCs: Mesenchymal stem cells PBMC: Peripheral blood mononuclear cells PHA: Phytohaemagglutinin PKM1/2: Pyruvate kinase M1/2 PKM2: Pyruvate kinase M2 PSR: Picrosi...
According to strong evidence, diabetes mellitus increases the risk of cognitive impairment. Mesenchymal stem cells have been shown to be potential therapeutic agents for neurological disorders. In the current study, we aimed to examine the effects of Wharton’s jelly-derived mesenchymal stem cell-condi...
Background: Although the expression of toll-like receptors (TLRs) on different types of human mesenchymal stem cells (hMSCs) has recently been reported, controversy remains regarding the presence of TLR4 as well as its engagement and impact on human Wharton's jelly-derived MSCs (hWJ-MSCs). Meth...
Exosomes isolated from Wharton’s jelly promote cell viability and cell migration in vitro To verify whether the positive effect of AGWJ on skin healing is via the exosomes, we subjected fibroblasts to the AGWJ-derived exosomes and performed a viability assay as well as a scratch assay in vitr...
The results of in vitro experiments show that human umbilical cord Wharton's jelly MSC-Exos (hWJMSC-Exos) can promote the migration and proliferation of bone marrow-derived MSCs (BMSCs) and the proliferation of chondrocytes. We also found that hWJMSC-Exos can promote the polarization of ...
There are comments on PubPeer for publication: Exosomes derived from human umbilical cord Wharton's jelly mesenchymal stem cells ameliorate experimental lymphedema (2021)
Thus, we aimed to develop a production methodology of Wharton's Jelly MSC (WJMSC) derived exosomes in a bioreactor and test the hypothesis that the exosome product would significantly reduce neonatal lung injury in a preclinical model of Bronchopulmonary Dysplasia....
Wharton jelly stem cell-based exosomes are known to have many properties, including other wound healing activities. In addition, considering both the structure and size of exosomes, its development as a drug delivery system is promising.Burcak Yavuz...
treatments are available for lymphedema.1-3 It is urgently needed to develop new experimental approaches and therapeutic strategies.3 In this study, we address a new role and mechanism of MSC-ex (human umbilical cord Wharton's jelly mesenchymal stem cells derived exosome) in lymphedema treatment....